The effects of Dendrobium species on the metabolic syndrome: A review
Metabolic syndrome (MetS) is known as a global health challenge with different types of health conditions such as hypertension, hyperglycemia, the increasing prevalence of obesity, and hyperlipidemia. Despite much recent scientific progress, the use of traditional herbal medicines with fewer side ef...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-07-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_21868_9badf5c4e8cad1fcae42afce313f6315.pdf |
| _version_ | 1797682705375166464 |
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| author | Zahra Oskouei Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh |
| author_facet | Zahra Oskouei Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh |
| author_sort | Zahra Oskouei |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is known as a global health challenge with different types of health conditions such as hypertension, hyperglycemia, the increasing prevalence of obesity, and hyperlipidemia. Despite much recent scientific progress, the use of traditional herbal medicines with fewer side effects is increasing worldwide. Dendrobium, the second-largest orchid genus, has been used as a natural source of drugs for the treatment of MetS. The beneficial effects of Dendrobium, including anti-hypertension, anti-hyperglycemia, anti-obesity, and anti-hyperlipidemic against MetS have been shown in the scientific evidence. The anti-oxidant and lipid-lowering effects of Dendrobium modulate hyperlipidemia via reducing lipid accumulation and maintaining lipid metabolism. Restoring pancreatic beta cells and regulating the insulin signaling pathway are involved in its antidiabetic properties. The hypotensive effects contribute to increasing nitric oxide (NO) generation and inhibiting extracellular signal-regulated kinase (ERK) signaling. More research projects, especially clinical trials, are needed to investigate the safety, efficacy, and pharmacokinetics of Dendrobium in patients. This review article provides, for the first time, comprehensive information about the efficacy of different species of Dendrobium. The described species can be a source of medicines for the treatment of MetS, which are reported in various evidence. |
| first_indexed | 2024-03-12T00:04:43Z |
| format | Article |
| id | doaj.art-f6a47f1122f6430fa8a05d78ebd883dd |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-03-12T00:04:43Z |
| publishDate | 2023-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-f6a47f1122f6430fa8a05d78ebd883dd2023-09-17T06:58:07ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742023-07-0126773875210.22038/ijbms.2023.65997.1451221868The effects of Dendrobium species on the metabolic syndrome: A reviewZahra Oskouei0Mahboobeh Ghasemzadeh Rahbardar1Hossein Hosseinzadeh2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranMetabolic syndrome (MetS) is known as a global health challenge with different types of health conditions such as hypertension, hyperglycemia, the increasing prevalence of obesity, and hyperlipidemia. Despite much recent scientific progress, the use of traditional herbal medicines with fewer side effects is increasing worldwide. Dendrobium, the second-largest orchid genus, has been used as a natural source of drugs for the treatment of MetS. The beneficial effects of Dendrobium, including anti-hypertension, anti-hyperglycemia, anti-obesity, and anti-hyperlipidemic against MetS have been shown in the scientific evidence. The anti-oxidant and lipid-lowering effects of Dendrobium modulate hyperlipidemia via reducing lipid accumulation and maintaining lipid metabolism. Restoring pancreatic beta cells and regulating the insulin signaling pathway are involved in its antidiabetic properties. The hypotensive effects contribute to increasing nitric oxide (NO) generation and inhibiting extracellular signal-regulated kinase (ERK) signaling. More research projects, especially clinical trials, are needed to investigate the safety, efficacy, and pharmacokinetics of Dendrobium in patients. This review article provides, for the first time, comprehensive information about the efficacy of different species of Dendrobium. The described species can be a source of medicines for the treatment of MetS, which are reported in various evidence.https://ijbms.mums.ac.ir/article_21868_9badf5c4e8cad1fcae42afce313f6315.pdfdendrobiumdiabeteshypertensiondyslipidemiametabolic syndrome |
| spellingShingle | Zahra Oskouei Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh The effects of Dendrobium species on the metabolic syndrome: A review Iranian Journal of Basic Medical Sciences dendrobium diabetes hypertension dyslipidemia metabolic syndrome |
| title | The effects of Dendrobium species on the metabolic syndrome: A review |
| title_full | The effects of Dendrobium species on the metabolic syndrome: A review |
| title_fullStr | The effects of Dendrobium species on the metabolic syndrome: A review |
| title_full_unstemmed | The effects of Dendrobium species on the metabolic syndrome: A review |
| title_short | The effects of Dendrobium species on the metabolic syndrome: A review |
| title_sort | effects of dendrobium species on the metabolic syndrome a review |
| topic | dendrobium diabetes hypertension dyslipidemia metabolic syndrome |
| url | https://ijbms.mums.ac.ir/article_21868_9badf5c4e8cad1fcae42afce313f6315.pdf |
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