Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chira...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-06-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.10.135 |
| _version_ | 1818369030255280128 |
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| author | Sabin Llona-Minguez Simon P. Mackay |
| author_facet | Sabin Llona-Minguez Simon P. Mackay |
| author_sort | Sabin Llona-Minguez |
| collection | DOAJ |
| description | A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules. |
| first_indexed | 2024-12-13T23:17:21Z |
| format | Article |
| id | doaj.art-f6a5198eb26f4f25862d9823e031a2fd |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-13T23:17:21Z |
| publishDate | 2014-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-f6a5198eb26f4f25862d9823e031a2fd2022-12-21T23:27:54ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972014-06-011011333133810.3762/bjoc.10.1351860-5397-10-135Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0)Sabin Llona-Minguez0Simon P. Mackay1Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 165 Cathedral Street, Glasgow, G4 0RE, United KingdomStrathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, 165 Cathedral Street, Glasgow, G4 0RE, United KingdomA convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with interesting three-dimensional character, including chiral cyclopentane-1,2-diol and -1,2,3-triol derivatives. This unusual substitution pattern provides a useful starting point for the discovery of novel bioactive molecules.https://doi.org/10.3762/bjoc.10.135diol synthesisnucleosidePreQ0stereoselective amine synthesistriol synthesis |
| spellingShingle | Sabin Llona-Minguez Simon P. Mackay Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) Beilstein Journal of Organic Chemistry diol synthesis nucleoside PreQ0 stereoselective amine synthesis triol synthesis |
| title | Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) |
| title_full | Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) |
| title_fullStr | Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) |
| title_full_unstemmed | Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) |
| title_short | Stereoselective synthesis of carbocyclic analogues of the nucleoside Q precursor (PreQ0) |
| title_sort | stereoselective synthesis of carbocyclic analogues of the nucleoside q precursor preq0 |
| topic | diol synthesis nucleoside PreQ0 stereoselective amine synthesis triol synthesis |
| url | https://doi.org/10.3762/bjoc.10.135 |
| work_keys_str_mv | AT sabinllonaminguez stereoselectivesynthesisofcarbocyclicanaloguesofthenucleosideqprecursorpreq0 AT simonpmackay stereoselectivesynthesisofcarbocyclicanaloguesofthenucleosideqprecursorpreq0 |