DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
Unresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06677-1 |
| _version_ | 1818977922633957376 |
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| author | Prasun Chakraborty Jeffrey T. J. Huang Kevin Hiom |
| author_facet | Prasun Chakraborty Jeffrey T. J. Huang Kevin Hiom |
| author_sort | Prasun Chakraborty |
| collection | DOAJ |
| description | Unresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3. |
| first_indexed | 2024-12-20T16:35:26Z |
| format | Article |
| id | doaj.art-f6a6b01d7c104d91b1ab6b903aaebe70 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:35:26Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f6a6b01d7c104d91b1ab6b903aaebe702022-12-21T19:33:11ZengNature PortfolioNature Communications2041-17232018-10-019111410.1038/s41467-018-06677-1DHX9 helicase promotes R-loop formation in cells with impaired RNA splicingPrasun Chakraborty0Jeffrey T. J. Huang1Kevin Hiom2Division of Cellular Medicine, School of Medicine, University of DundeeBiomarker and Drug Analysis Core Facility, School of Medicine, University of DundeeDivision of Cellular Medicine, School of Medicine, University of DundeeUnresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3.https://doi.org/10.1038/s41467-018-06677-1 |
| spellingShingle | Prasun Chakraborty Jeffrey T. J. Huang Kevin Hiom DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing Nature Communications |
| title | DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing |
| title_full | DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing |
| title_fullStr | DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing |
| title_full_unstemmed | DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing |
| title_short | DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing |
| title_sort | dhx9 helicase promotes r loop formation in cells with impaired rna splicing |
| url | https://doi.org/10.1038/s41467-018-06677-1 |
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