Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer
<p>Abstract</p> <p>Background</p> <p>Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how mycoplasmas could possi...
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| Format: | Article |
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BMC
2011-06-01
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| Series: | BMC Cancer |
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| Online Access: | http://www.biomedcentral.com/1471-2407/11/233 |
| _version_ | 1818835365954322432 |
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| author | Li Chen-zhong Sakamoto Noburo Porvasnik Stacy Chang Myron Goodison Steve Urbanek Cydney Boehlein Susan K Rosser Charles J |
| author_facet | Li Chen-zhong Sakamoto Noburo Porvasnik Stacy Chang Myron Goodison Steve Urbanek Cydney Boehlein Susan K Rosser Charles J |
| author_sort | Li Chen-zhong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how mycoplasmas could possibly initiate and propagate cancers of the prostate. Specifically, <it>Mycoplasma hyorhinis </it>encoded protein p37 was found to promote invasion of prostate cancer cells and cause changes in growth, morphology and gene expression of these cells to a more aggressive phenotype. Moreover, we found that chronic exposure of benign human prostate cells to <it>M. hyorhinis </it>resulted in significant phenotypic and karyotypic changes that ultimately resulted in the malignant transformation of the benign cells. In this study, we set out to investigate another potential link between mycoplasma and human prostate cancer.</p> <p>Methods</p> <p>We report the incidence of men with prostate cancer and benign prostatic hyperplasia (BPH) being seropositive for <it>M. hyorhinis</it>. Antibodies to <it>M. hyorhinis </it>were surveyed by a novel indirect enzyme-linked immunosorbent assay (ELISA) in serum samples collected from men presenting to an outpatient Urology clinic for BPH (N = 105) or prostate cancer (N = 114) from 2006-2009.</p> <p>Results</p> <p>A seropositive rate of 36% in men with BPH and 52% in men with prostate cancer was reported, thus leading us to speculate a possible connection between <it>M. hyorhinis </it>exposure with prostate cancer.</p> <p>Conclusions</p> <p>These results further support a potential exacerbating role for mycoplasma in the development of prostate cancer.</p> |
| first_indexed | 2024-12-19T02:49:34Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-19T02:49:34Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f6a78a7df0c54d20842935dcbc1f76a02022-12-21T20:38:43ZengBMCBMC Cancer1471-24072011-06-0111123310.1186/1471-2407-11-233Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancerLi Chen-zhongSakamoto NoburoPorvasnik StacyChang MyronGoodison SteveUrbanek CydneyBoehlein Susan KRosser Charles J<p>Abstract</p> <p>Background</p> <p>Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how mycoplasmas could possibly initiate and propagate cancers of the prostate. Specifically, <it>Mycoplasma hyorhinis </it>encoded protein p37 was found to promote invasion of prostate cancer cells and cause changes in growth, morphology and gene expression of these cells to a more aggressive phenotype. Moreover, we found that chronic exposure of benign human prostate cells to <it>M. hyorhinis </it>resulted in significant phenotypic and karyotypic changes that ultimately resulted in the malignant transformation of the benign cells. In this study, we set out to investigate another potential link between mycoplasma and human prostate cancer.</p> <p>Methods</p> <p>We report the incidence of men with prostate cancer and benign prostatic hyperplasia (BPH) being seropositive for <it>M. hyorhinis</it>. Antibodies to <it>M. hyorhinis </it>were surveyed by a novel indirect enzyme-linked immunosorbent assay (ELISA) in serum samples collected from men presenting to an outpatient Urology clinic for BPH (N = 105) or prostate cancer (N = 114) from 2006-2009.</p> <p>Results</p> <p>A seropositive rate of 36% in men with BPH and 52% in men with prostate cancer was reported, thus leading us to speculate a possible connection between <it>M. hyorhinis </it>exposure with prostate cancer.</p> <p>Conclusions</p> <p>These results further support a potential exacerbating role for mycoplasma in the development of prostate cancer.</p>http://www.biomedcentral.com/1471-2407/11/233<it>Mycoplasma hyorhinis</it>ELISAcancerprostate |
| spellingShingle | Li Chen-zhong Sakamoto Noburo Porvasnik Stacy Chang Myron Goodison Steve Urbanek Cydney Boehlein Susan K Rosser Charles J Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer BMC Cancer <it>Mycoplasma hyorhinis</it> ELISA cancer prostate |
| title | Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer |
| title_full | Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer |
| title_fullStr | Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer |
| title_full_unstemmed | Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer |
| title_short | Detection of antibodies directed at <it>M. hyorhinis </it>p37 in the serum of men with newly diagnosed prostate cancer |
| title_sort | detection of antibodies directed at it m hyorhinis it p37 in the serum of men with newly diagnosed prostate cancer |
| topic | <it>Mycoplasma hyorhinis</it> ELISA cancer prostate |
| url | http://www.biomedcentral.com/1471-2407/11/233 |
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