Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer
Abstract The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-04-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-021-03532-z |
| _version_ | 1827844209398251520 |
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| author | Qian Zhang Wen Wang Hongyuan Shen Hongyu Tao Yating Wu Liyuan Ma Guangfei Yang Ruijiao Chang Jiaxing Wang Hanfei Zhang Chenyu Wang Furong Zhang Jiaojiao Qi Chengrong Mi |
| author_facet | Qian Zhang Wen Wang Hongyuan Shen Hongyu Tao Yating Wu Liyuan Ma Guangfei Yang Ruijiao Chang Jiaxing Wang Hanfei Zhang Chenyu Wang Furong Zhang Jiaojiao Qi Chengrong Mi |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Abstract The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core–shell structure. The synergistic Ce6/PFP/DTX/PLGA nanoparticles (CPDP NPs) featured with excellent biocompatibility and stability primarily enable its further application. Upon low-intensity focused ultrasound (LIFU) irradiation, the enhanced ultrasound imaging could be revealed both in vitro and in vivo. More importantly, combined with LIFU, the nanoparticles exhibit intriguing antitumor capability through Ce6-induced cytotoxic reactive oxygen species as well as DTX releasing to generate a concerted therapeutic efficiency. Furthermore, this treating strategy actives a strong anti-metastasis capability by which lung metastatic nodules have been significantly reduced. The results indicate that the SDT-oriented nanoplatform combined with chemotherapy could be provided as a promising approach in elevating effective synergistic therapy and suppressing lung metastasis of breast cancer. |
| first_indexed | 2024-03-12T08:38:18Z |
| format | Article |
| id | doaj.art-f6a871bbbe3749b3abd15dac43f6be94 |
| institution | Directory Open Access Journal |
| issn | 1556-276X |
| language | English |
| last_indexed | 2024-03-12T08:38:18Z |
| publishDate | 2021-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-f6a871bbbe3749b3abd15dac43f6be942023-09-02T17:07:07ZengSpringerOpenNanoscale Research Letters1556-276X2021-04-0116111510.1186/s11671-021-03532-zLow-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast CancerQian Zhang0Wen Wang1Hongyuan Shen2Hongyu Tao3Yating Wu4Liyuan Ma5Guangfei Yang6Ruijiao Chang7Jiaxing Wang8Hanfei Zhang9Chenyu Wang10Furong Zhang11Jiaojiao Qi12Chengrong Mi13Department of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityDepartment of Ultrasound, General Hospital of Ningxia Medical UniversityAbstract The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core–shell structure. The synergistic Ce6/PFP/DTX/PLGA nanoparticles (CPDP NPs) featured with excellent biocompatibility and stability primarily enable its further application. Upon low-intensity focused ultrasound (LIFU) irradiation, the enhanced ultrasound imaging could be revealed both in vitro and in vivo. More importantly, combined with LIFU, the nanoparticles exhibit intriguing antitumor capability through Ce6-induced cytotoxic reactive oxygen species as well as DTX releasing to generate a concerted therapeutic efficiency. Furthermore, this treating strategy actives a strong anti-metastasis capability by which lung metastatic nodules have been significantly reduced. The results indicate that the SDT-oriented nanoplatform combined with chemotherapy could be provided as a promising approach in elevating effective synergistic therapy and suppressing lung metastasis of breast cancer.https://doi.org/10.1186/s11671-021-03532-zNanoparticleSonodynamic therapyContrast-enhanced ultrasoundAnti-metastasisLIFU |
| spellingShingle | Qian Zhang Wen Wang Hongyuan Shen Hongyu Tao Yating Wu Liyuan Ma Guangfei Yang Ruijiao Chang Jiaxing Wang Hanfei Zhang Chenyu Wang Furong Zhang Jiaojiao Qi Chengrong Mi Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer Nanoscale Research Letters Nanoparticle Sonodynamic therapy Contrast-enhanced ultrasound Anti-metastasis LIFU |
| title | Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer |
| title_full | Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer |
| title_fullStr | Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer |
| title_full_unstemmed | Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer |
| title_short | Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer |
| title_sort | low intensity focused ultrasound augmented multifunctional nanoparticles for integrating ultrasound imaging and synergistic therapy of metastatic breast cancer |
| topic | Nanoparticle Sonodynamic therapy Contrast-enhanced ultrasound Anti-metastasis LIFU |
| url | https://doi.org/10.1186/s11671-021-03532-z |
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