Genetic and epigenetic alterations of colorectal cancer
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent eviden...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of Intestinal Diseases
2018-07-01
|
| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-16-327.pdf |
| _version_ | 1811308908687392768 |
|---|---|
| author | Sung Noh Hong |
| author_facet | Sung Noh Hong |
| author_sort | Sung Noh Hong |
| collection | DOAJ |
| description | Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC. |
| first_indexed | 2024-04-13T09:32:51Z |
| format | Article |
| id | doaj.art-f6a8add86eec4c2bacae08511ea348ae |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-04-13T09:32:51Z |
| publishDate | 2018-07-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-f6a8add86eec4c2bacae08511ea348ae2022-12-22T02:52:12ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562018-07-0116332733710.5217/ir.2018.16.3.327300Genetic and epigenetic alterations of colorectal cancerSung Noh Hong0Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, .KoreaColorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC.http://www.irjournal.org/upload/pdf/ir-16-327.pdfColorectal neoplasmsMutationEpigenesis, genetic |
| spellingShingle | Sung Noh Hong Genetic and epigenetic alterations of colorectal cancer Intestinal Research Colorectal neoplasms Mutation Epigenesis, genetic |
| title | Genetic and epigenetic alterations of colorectal cancer |
| title_full | Genetic and epigenetic alterations of colorectal cancer |
| title_fullStr | Genetic and epigenetic alterations of colorectal cancer |
| title_full_unstemmed | Genetic and epigenetic alterations of colorectal cancer |
| title_short | Genetic and epigenetic alterations of colorectal cancer |
| title_sort | genetic and epigenetic alterations of colorectal cancer |
| topic | Colorectal neoplasms Mutation Epigenesis, genetic |
| url | http://www.irjournal.org/upload/pdf/ir-16-327.pdf |
| work_keys_str_mv | AT sungnohhong geneticandepigeneticalterationsofcolorectalcancer |