Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis
Introduction: Dietary oligosaccharides can impact the gut microbiota and confer tremendous health benefits. Objectives: The aim of this study was to determine the impact of a novel functional oligosaccharide, neoagarotetraose (NAT), on aging in mice. Methods: 8-month-old C57BL/6J mice as the natural...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123223001200 |
| _version_ | 1827803706339360768 |
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| author | Tao Li Shaoqing Yang Xiaoyan Liu Yanxiao Li Zhenglong Gu Zhengqiang Jiang |
| author_facet | Tao Li Shaoqing Yang Xiaoyan Liu Yanxiao Li Zhenglong Gu Zhengqiang Jiang |
| author_sort | Tao Li |
| collection | DOAJ |
| description | Introduction: Dietary oligosaccharides can impact the gut microbiota and confer tremendous health benefits. Objectives: The aim of this study was to determine the impact of a novel functional oligosaccharide, neoagarotetraose (NAT), on aging in mice. Methods: 8-month-old C57BL/6J mice as the natural aging mice model were orally administered with NAT for 12 months. The preventive effect of NAT in Alzheimer’s disease (AD) mice was further evaluated. Aging related indicators, neuropathology, gut microbiota and short-chain fatty acids (SCFAs) in cecal contents were analyzed. Results: NAT treatment extended the lifespan of these mice by up to 33.3 %. Furthermore, these mice showed the improved aging characteristics and decreased injuries in cerebral neurons. Dietary NAT significantly delayed DNA damage in the brain, and inhibited reduction of tight junction protein in the colon. A significant increase at gut bacterial genus level (such as Lactobacillus, Butyricimonas, and Akkermansia) accompanied by increasing concentrations of SCFAs in cecal contents was observed after NAT treatment. Functional profiling of gut microbiota composition indicated that NAT treatment regulated the glucolipid and bile acid-related metabolic pathways. Interestingly, NAT treatment ameliorated cognitive impairment, attenuated amyloid-β (Aβ) and Tau pathology, and regulated the gut microbiota composition and SCFAs receptor-related pathway of Alzheimer’s disease (AD) mice. Conclusion: NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases. |
| first_indexed | 2024-03-11T20:58:16Z |
| format | Article |
| id | doaj.art-f6a94fd94cb744399a47081d566d9775 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-03-11T20:58:16Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-f6a94fd94cb744399a47081d566d97752023-09-30T04:54:24ZengElsevierJournal of Advanced Research2090-12322023-10-0152119134Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axisTao Li0Shaoqing Yang1Xiaoyan Liu2Yanxiao Li3Zhenglong Gu4Zhengqiang Jiang5Key Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, ChinaKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, ChinaKey Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, ChinaDepartment of Nutrition and Health, College of Engineering, China Agricultural University, Beijing, ChinaDivision of Nutritional Sciences, Cornell University, NY, USA; Greater Bay Area Institute of Precision Medicine (Guangzhou), Nansha District, Guangzhou 511400, China; Institute of Life Sciences, Fudan University, Shanghai 200433, China; Corresponding authors at: Cornell University, New York, USA (Z. Gu). College of Food Science and Nutritional Engineering, China Agricultural University, No.17 Qinghua Donglu, Haidian District, Beijing 100083, China (Z. Jiang).Key Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China; Corresponding authors at: Cornell University, New York, USA (Z. Gu). College of Food Science and Nutritional Engineering, China Agricultural University, No.17 Qinghua Donglu, Haidian District, Beijing 100083, China (Z. Jiang).Introduction: Dietary oligosaccharides can impact the gut microbiota and confer tremendous health benefits. Objectives: The aim of this study was to determine the impact of a novel functional oligosaccharide, neoagarotetraose (NAT), on aging in mice. Methods: 8-month-old C57BL/6J mice as the natural aging mice model were orally administered with NAT for 12 months. The preventive effect of NAT in Alzheimer’s disease (AD) mice was further evaluated. Aging related indicators, neuropathology, gut microbiota and short-chain fatty acids (SCFAs) in cecal contents were analyzed. Results: NAT treatment extended the lifespan of these mice by up to 33.3 %. Furthermore, these mice showed the improved aging characteristics and decreased injuries in cerebral neurons. Dietary NAT significantly delayed DNA damage in the brain, and inhibited reduction of tight junction protein in the colon. A significant increase at gut bacterial genus level (such as Lactobacillus, Butyricimonas, and Akkermansia) accompanied by increasing concentrations of SCFAs in cecal contents was observed after NAT treatment. Functional profiling of gut microbiota composition indicated that NAT treatment regulated the glucolipid and bile acid-related metabolic pathways. Interestingly, NAT treatment ameliorated cognitive impairment, attenuated amyloid-β (Aβ) and Tau pathology, and regulated the gut microbiota composition and SCFAs receptor-related pathway of Alzheimer’s disease (AD) mice. Conclusion: NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.http://www.sciencedirect.com/science/article/pii/S2090123223001200NeoagarotetraoseLongevityNeuronal injuryGut microbiotaAlzheimer’s disease |
| spellingShingle | Tao Li Shaoqing Yang Xiaoyan Liu Yanxiao Li Zhenglong Gu Zhengqiang Jiang Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis Journal of Advanced Research Neoagarotetraose Longevity Neuronal injury Gut microbiota Alzheimer’s disease |
| title | Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis |
| title_full | Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis |
| title_fullStr | Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis |
| title_full_unstemmed | Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis |
| title_short | Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis |
| title_sort | dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota gut brain axis |
| topic | Neoagarotetraose Longevity Neuronal injury Gut microbiota Alzheimer’s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2090123223001200 |
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