Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research

Isolation of living dopaminergic neurons labeled with a fluorescent ligand of the dopamine transporter from mouse substantia nigra as a new tool for basic and applied research

Dopaminergic neurons (DNs) of the nigrostriatal system control the motor function, and their degeneration leads to the development of Parkinson’s disease (PD). A stumbling block in the study of DNs in the whole substantia nigra (SN) is the lack of tools to analyze the expression of most of the genes...

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Bibliographic Details
Main Authors: Dmitry Troshev, Victor Blokhin, Valeria Ukrainskaya, Anna Kolacheva, Michael Ugrumov
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
dopaminergic neurons
substantia nigra
Parkinson’s disease
FACS
C57BL/6 mice
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1020070/full

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