<i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery
The essential oil extracted from the leaves of <i>Piper aduncum</i>, an aromatic plant from the Amazon region, is rich in dillapiole and presents anti-inflammatory activity. In this study, nanoemulsions (NE) and nanostructured lipid carriers (NLC), which are biocompatible nanostructured...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2525 |
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| author | Simone Braga Carneiro Tainá Kreutz Renata Pereira Limberger Helder Ferreira Teixeira Valdir Florêncio da Veiga Júnior Letícia Scherer Koester |
| author_facet | Simone Braga Carneiro Tainá Kreutz Renata Pereira Limberger Helder Ferreira Teixeira Valdir Florêncio da Veiga Júnior Letícia Scherer Koester |
| author_sort | Simone Braga Carneiro |
| collection | DOAJ |
| description | The essential oil extracted from the leaves of <i>Piper aduncum</i>, an aromatic plant from the Amazon region, is rich in dillapiole and presents anti-inflammatory activity. In this study, nanoemulsions (NE) and nanostructured lipid carriers (NLC), which are biocompatible nanostructured systems of a lipid nature, were prepared by high-pressure homogenization for the yet unexplored skin delivery of dillapiole. The addition of hydroxyethylcellulose produced hydrogel-thickened NE or NLC in view to improving the viscosity and skin adherence of the nanoformulations. Formulations were characterized with respect to dillapiole content, droplet size, polydispersity index, zeta potential, morphology, rheological behavior, bioadhesion, skin permeation profile, and in vitro irritancy (HET-CAM). The formulations developed presented spherical, homogeneous nanometric particle size (around 130 nm), narrow polydispersity index (<0.3), and negative zeta potential (around −40 mV). Dillapiole content was slightly lower in NLC compared to NE since the production process involves heating. The hydrogels containing nanocarriers showed pseudoplastic behavior with bioadhesive characteristics. The developed formulations exhibited a controlled release profile, dillapiole delivery up to the dermis, the layer of interest for anti-inflammatory potential, and low irritant potential in the chorioallantoic membrane (HET-CAM). Both hydrogels-thickened NE and NLC seemed to be promising formulations for skin delivery of <i>Piper aduncum</i> essential oil. |
| first_indexed | 2024-03-09T18:04:30Z |
| format | Article |
| id | doaj.art-f6ae78dbc8b340b9a041e11c52886d4a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:04:30Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f6ae78dbc8b340b9a041e11c52886d4a2023-11-24T09:37:14ZengMDPI AGPharmaceutics1999-49232022-11-011411252510.3390/pharmaceutics14112525<i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin DeliverySimone Braga Carneiro0Tainá Kreutz1Renata Pereira Limberger2Helder Ferreira Teixeira3Valdir Florêncio da Veiga Júnior4Letícia Scherer Koester5Programa de Pós-Graduação em Inovação Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Av. Gal. Rodrigo Octávio, Coroado I, 1200, Manaus 69067-005, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, BrazilPrograma de Pós-Graduação em Química, Instituto Militar de Engenharia, Praça General Tibúrcio, Urca, 80, Rio de Janeiro 22290-270, BrazilPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, BrazilThe essential oil extracted from the leaves of <i>Piper aduncum</i>, an aromatic plant from the Amazon region, is rich in dillapiole and presents anti-inflammatory activity. In this study, nanoemulsions (NE) and nanostructured lipid carriers (NLC), which are biocompatible nanostructured systems of a lipid nature, were prepared by high-pressure homogenization for the yet unexplored skin delivery of dillapiole. The addition of hydroxyethylcellulose produced hydrogel-thickened NE or NLC in view to improving the viscosity and skin adherence of the nanoformulations. Formulations were characterized with respect to dillapiole content, droplet size, polydispersity index, zeta potential, morphology, rheological behavior, bioadhesion, skin permeation profile, and in vitro irritancy (HET-CAM). The formulations developed presented spherical, homogeneous nanometric particle size (around 130 nm), narrow polydispersity index (<0.3), and negative zeta potential (around −40 mV). Dillapiole content was slightly lower in NLC compared to NE since the production process involves heating. The hydrogels containing nanocarriers showed pseudoplastic behavior with bioadhesive characteristics. The developed formulations exhibited a controlled release profile, dillapiole delivery up to the dermis, the layer of interest for anti-inflammatory potential, and low irritant potential in the chorioallantoic membrane (HET-CAM). Both hydrogels-thickened NE and NLC seemed to be promising formulations for skin delivery of <i>Piper aduncum</i> essential oil.https://www.mdpi.com/1999-4923/14/11/2525essential oil<i>Piper aduncum</i>dillapiolenanotechnologyskin permeationanti-inflammatory |
| spellingShingle | Simone Braga Carneiro Tainá Kreutz Renata Pereira Limberger Helder Ferreira Teixeira Valdir Florêncio da Veiga Júnior Letícia Scherer Koester <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery Pharmaceutics essential oil <i>Piper aduncum</i> dillapiole nanotechnology skin permeation anti-inflammatory |
| title | <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery |
| title_full | <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery |
| title_fullStr | <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery |
| title_full_unstemmed | <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery |
| title_short | <i>Piper aduncum</i> Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery |
| title_sort | i piper aduncum i essential oil rich in dillapiole development of hydrogel thickened nanoemulsion and nanostructured lipid carrier intended for skin delivery |
| topic | essential oil <i>Piper aduncum</i> dillapiole nanotechnology skin permeation anti-inflammatory |
| url | https://www.mdpi.com/1999-4923/14/11/2525 |
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