Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment
Acne inversa (AI) is a disabilitating chronic inflammatory disease with major negative impact on quality of life and significant co-morbidities. This is an important link to insights into immune dysfunction, which stimulated therapeutic approaches like tumor necrosis-α inhibitor therapy. This new of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Dermatology Online Journal |
| Subjects: | |
| Online Access: | http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=1;spage=2;epage=11;aulast=Wollina |
| _version_ | 1828435577243959296 |
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| author | Uwe Wollina André Koch Birgit Heinig Thomas Kittner Andreas Nowak |
| author_facet | Uwe Wollina André Koch Birgit Heinig Thomas Kittner Andreas Nowak |
| author_sort | Uwe Wollina |
| collection | DOAJ |
| description | Acne inversa (AI) is a disabilitating chronic inflammatory disease with major negative impact on quality of life and significant co-morbidities. This is an important link to insights into immune dysfunction, which stimulated therapeutic approaches like tumor necrosis-α inhibitor therapy. This new off-label drug treatment is particularly beneficial when used in combination with wide excision of inflamed skin and subcutaneous tissue. Retinoids have been reported to be helpful in secondary prevention. The standard of therapy in advanced cases is surgery with wide excisions and healing by secondary intention. This treatment results in significant reduction of complaints and achieves satisfactory body contouring. |
| first_indexed | 2024-12-10T19:09:39Z |
| format | Article |
| id | doaj.art-f6af9a6b64314ba5a37be7b45d55824f |
| institution | Directory Open Access Journal |
| issn | 2229-5178 |
| language | English |
| last_indexed | 2024-12-10T19:09:39Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj.art-f6af9a6b64314ba5a37be7b45d55824f2022-12-22T01:36:47ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782013-01-014121110.4103/2229-5178.105454Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatmentUwe WollinaAndré KochBirgit HeinigThomas KittnerAndreas NowakAcne inversa (AI) is a disabilitating chronic inflammatory disease with major negative impact on quality of life and significant co-morbidities. This is an important link to insights into immune dysfunction, which stimulated therapeutic approaches like tumor necrosis-α inhibitor therapy. This new off-label drug treatment is particularly beneficial when used in combination with wide excision of inflamed skin and subcutaneous tissue. Retinoids have been reported to be helpful in secondary prevention. The standard of therapy in advanced cases is surgery with wide excisions and healing by secondary intention. This treatment results in significant reduction of complaints and achieves satisfactory body contouring.http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=1;spage=2;epage=11;aulast=WollinaAcne inversaco-morbiditiesdrug therapyhidradenitis suppurativaimmune dysfunctionsradical surgeryretinoidstumor necrosis factor-α |
| spellingShingle | Uwe Wollina André Koch Birgit Heinig Thomas Kittner Andreas Nowak Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment Indian Dermatology Online Journal Acne inversa co-morbidities drug therapy hidradenitis suppurativa immune dysfunctions radical surgery retinoids tumor necrosis factor-α |
| title | Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment |
| title_full | Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment |
| title_fullStr | Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment |
| title_full_unstemmed | Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment |
| title_short | Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment |
| title_sort | acne inversa hidradenitis suppurativa a review with a focus on pathogenesis and treatment |
| topic | Acne inversa co-morbidities drug therapy hidradenitis suppurativa immune dysfunctions radical surgery retinoids tumor necrosis factor-α |
| url | http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=1;spage=2;epage=11;aulast=Wollina |
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