Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series
As adolescents started to be vaccinated against coronavirus disease 2019 (COVID-19), suspected myocarditis and pericarditis related to the vaccine were reported in adolescents. According to the Korea Disease Control and Prevention Agency (KDCA), 2,796,270 persons aged 12–18 years were fully vaccinat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/5/693 |
| _version_ | 1797500812174295040 |
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| author | Da-Eun Roh Hyejin Na Jung-Eun Kwon Insu Choi Yeo-Hyang Kim Hwa-Jin Cho |
| author_facet | Da-Eun Roh Hyejin Na Jung-Eun Kwon Insu Choi Yeo-Hyang Kim Hwa-Jin Cho |
| author_sort | Da-Eun Roh |
| collection | DOAJ |
| description | As adolescents started to be vaccinated against coronavirus disease 2019 (COVID-19), suspected myocarditis and pericarditis related to the vaccine were reported in adolescents. According to the Korea Disease Control and Prevention Agency (KDCA), 2,796,270 persons aged 12–18 years were fully vaccinated by December 8. Among these, 9223 adverse events were reported (0.33%). We aimed to elucidate the clinical courses and short-term outcomes for adolescents aged 12–18 with cardiac symptoms and suspected myo- or peri-carditis related to COVID-19 vaccination in South Korea. Methods: We retrospectively collected data on patients ≤ 18 years of age who had suspected myocarditis or pericarditis within 30 days of COVID-19 vaccination, from July 2021 to January 2022. Results: We reported on 40 adolescents in different South Korean provinces at two centers. Twenty-six cases (65%) were male, and the median age was 16 years (range, 13–18; IQR 14.5–17). Twenty-five cases (62.5%) occurred at the first dose, and fifteen (37.5%) occurred after the second dose. Symptoms started at a median of 2 days (range 0–29 days; IQR 1–5 days) after vaccination. The patients were treated with nonsteroidal anti-inflammatory drugs (77.5%), intravenous immunoglobulin (2.5%), glucocorticoids (20%), colchicine (5%), or no therapy (15%). Five patients (12.5%) required intensive care unit admission; one patient needed inotropic/vasoactive support. No patients required extracorporeal membrane oxygenation or died. The median hospital stay was one day (range 0–8 days; IQR 0–2 days). Twenty-one patients (52.5%) had an abnormal electrocardiogram; among these, seven patients had an elevated ST segment, six patients (15%) had decreased ejection fraction (<55%), and LV function was completely recovered in all of them. Conclusions: Most cases of suspected myocarditis after COVID-19 vaccination in adolescents ≤ 18 years had mild symptoms and clinical courses, as well as a complete recovery. Further studies are needed to evaluate long-term outcomes. |
| first_indexed | 2024-03-10T03:09:14Z |
| format | Article |
| id | doaj.art-f6afcaefe28746788e272f20609af3cc |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T03:09:14Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f6afcaefe28746788e272f20609af3cc2023-11-23T10:31:01ZengMDPI AGChildren2227-90672022-05-019569310.3390/children9050693Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case SeriesDa-Eun Roh0Hyejin Na1Jung-Eun Kwon2Insu Choi3Yeo-Hyang Kim4Hwa-Jin Cho5Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41566, KoreaDepartment of Pediatrics, Chonnam National University Children’s Hospital, Gwangju 61469, KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41566, KoreaDepartment of Pediatrics, Chonnam National University Children’s Hospital, Gwangju 61469, KoreaDepartment of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41566, KoreaDepartment of Pediatrics, Chonnam National University Children’s Hospital, Gwangju 61469, KoreaAs adolescents started to be vaccinated against coronavirus disease 2019 (COVID-19), suspected myocarditis and pericarditis related to the vaccine were reported in adolescents. According to the Korea Disease Control and Prevention Agency (KDCA), 2,796,270 persons aged 12–18 years were fully vaccinated by December 8. Among these, 9223 adverse events were reported (0.33%). We aimed to elucidate the clinical courses and short-term outcomes for adolescents aged 12–18 with cardiac symptoms and suspected myo- or peri-carditis related to COVID-19 vaccination in South Korea. Methods: We retrospectively collected data on patients ≤ 18 years of age who had suspected myocarditis or pericarditis within 30 days of COVID-19 vaccination, from July 2021 to January 2022. Results: We reported on 40 adolescents in different South Korean provinces at two centers. Twenty-six cases (65%) were male, and the median age was 16 years (range, 13–18; IQR 14.5–17). Twenty-five cases (62.5%) occurred at the first dose, and fifteen (37.5%) occurred after the second dose. Symptoms started at a median of 2 days (range 0–29 days; IQR 1–5 days) after vaccination. The patients were treated with nonsteroidal anti-inflammatory drugs (77.5%), intravenous immunoglobulin (2.5%), glucocorticoids (20%), colchicine (5%), or no therapy (15%). Five patients (12.5%) required intensive care unit admission; one patient needed inotropic/vasoactive support. No patients required extracorporeal membrane oxygenation or died. The median hospital stay was one day (range 0–8 days; IQR 0–2 days). Twenty-one patients (52.5%) had an abnormal electrocardiogram; among these, seven patients had an elevated ST segment, six patients (15%) had decreased ejection fraction (<55%), and LV function was completely recovered in all of them. Conclusions: Most cases of suspected myocarditis after COVID-19 vaccination in adolescents ≤ 18 years had mild symptoms and clinical courses, as well as a complete recovery. Further studies are needed to evaluate long-term outcomes.https://www.mdpi.com/2227-9067/9/5/693COVID-19vaccinechest painmyocarditis |
| spellingShingle | Da-Eun Roh Hyejin Na Jung-Eun Kwon Insu Choi Yeo-Hyang Kim Hwa-Jin Cho Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series Children COVID-19 vaccine chest pain myocarditis |
| title | Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series |
| title_full | Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series |
| title_fullStr | Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series |
| title_full_unstemmed | Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series |
| title_short | Chest Pain and Suspected Myocarditis Related to COVID-19 Vaccination in Adolescents—A Case Series |
| title_sort | chest pain and suspected myocarditis related to covid 19 vaccination in adolescents a case series |
| topic | COVID-19 vaccine chest pain myocarditis |
| url | https://www.mdpi.com/2227-9067/9/5/693 |
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