Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

Key protein adapters couple translation to mRNA decay on specific classes of problematic mRNAs in eukaryotes. Slow decoding on non-optimal codons leads to codon-optimality-mediated decay (COMD) and prolonged arrest at stall sites leads to no-go decay (NGD). The identities of the decay factors underl...

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Bibliographic Details
Main Authors: Anthony J Veltri, Karole N D'Orazio, Laura N Lessen, Raphael Loll-Krippleber, Grant W Brown, Rachel Green
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
no-go decay
codon-optimality-mediated decay
SYH1
quality control
translation
mRNA decay
Online Access:https://elifesciences.org/articles/76038

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