Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness
Abstract Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogene...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22655-6 |
| _version_ | 1811256981435973632 |
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| author | Naoko Katsurada Tatsuya Nagano Masatsugu Yamamoto Tatsunori Kiriu Ryota Dokuni Hiroshi Kamiryo Ai Yoshioka Atsushi Fukunaga Chikako Nishigori Yoshihiro Nishimura Kazuyuki Kobayashi |
| author_facet | Naoko Katsurada Tatsuya Nagano Masatsugu Yamamoto Tatsunori Kiriu Ryota Dokuni Hiroshi Kamiryo Ai Yoshioka Atsushi Fukunaga Chikako Nishigori Yoshihiro Nishimura Kazuyuki Kobayashi |
| author_sort | Naoko Katsurada |
| collection | DOAJ |
| description | Abstract Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in the prevalence of bronchial asthma among the subtypes. We analyzed bronchial responsiveness using the methacholine dose indicator Dmin, respiratory symptoms, and exhaled nitric oxide (FeNO). Median log10 Dmin (interquartile range) of patients with conventional SAT-CholU (n = 11), CholU-PA (n = 11), and CholU-Anhd (n = 11) was 0.381 (− 0.829, 1.079), 0.717 (0.249, 0.787), and 1.318 (0.121, 1.699), respectively (p = 0.516). Respiratory symptoms were less frequently observed in CholU-Anhd than in conventional SAT-CholU or CholU-PA. FeNO of patients with conventional SAT-CholU, CholU-PA, and CholU-Anhd was 23 (18.5, 65.0), 39 (32.0, 59.5), and 25 (19.0, 33.0) ppb, respectively (p = 0.237). Nine% of conventional SAT-CholU patients and more than half of CholU-PA patients required treatment for asthma. Log Dmin tended to be lower in patients with SAT-CholU than in those with CholU-Anhd. CholU-PA might be associated with asthma. |
| first_indexed | 2024-04-12T17:49:30Z |
| format | Article |
| id | doaj.art-f6b1f0ffbef44a4b99e19c3a4638f9ae |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T17:49:30Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f6b1f0ffbef44a4b99e19c3a4638f9ae2022-12-22T03:22:32ZengNature PortfolioScientific Reports2045-23222022-10-011211610.1038/s41598-022-22655-6Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsivenessNaoko Katsurada0Tatsuya Nagano1Masatsugu Yamamoto2Tatsunori Kiriu3Ryota Dokuni4Hiroshi Kamiryo5Ai Yoshioka6Atsushi Fukunaga7Chikako Nishigori8Yoshihiro Nishimura9Kazuyuki Kobayashi10Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of MedicineDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of MedicineDivision of Dermatology, Department of Internal Related, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of MedicineAbstract Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in the prevalence of bronchial asthma among the subtypes. We analyzed bronchial responsiveness using the methacholine dose indicator Dmin, respiratory symptoms, and exhaled nitric oxide (FeNO). Median log10 Dmin (interquartile range) of patients with conventional SAT-CholU (n = 11), CholU-PA (n = 11), and CholU-Anhd (n = 11) was 0.381 (− 0.829, 1.079), 0.717 (0.249, 0.787), and 1.318 (0.121, 1.699), respectively (p = 0.516). Respiratory symptoms were less frequently observed in CholU-Anhd than in conventional SAT-CholU or CholU-PA. FeNO of patients with conventional SAT-CholU, CholU-PA, and CholU-Anhd was 23 (18.5, 65.0), 39 (32.0, 59.5), and 25 (19.0, 33.0) ppb, respectively (p = 0.237). Nine% of conventional SAT-CholU patients and more than half of CholU-PA patients required treatment for asthma. Log Dmin tended to be lower in patients with SAT-CholU than in those with CholU-Anhd. CholU-PA might be associated with asthma.https://doi.org/10.1038/s41598-022-22655-6 |
| spellingShingle | Naoko Katsurada Tatsuya Nagano Masatsugu Yamamoto Tatsunori Kiriu Ryota Dokuni Hiroshi Kamiryo Ai Yoshioka Atsushi Fukunaga Chikako Nishigori Yoshihiro Nishimura Kazuyuki Kobayashi Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness Scientific Reports |
| title | Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| title_full | Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| title_fullStr | Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| title_full_unstemmed | Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| title_short | Cross-sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| title_sort | cross sectional study of cholinergic urticaria subtypes and bronchial hyperresponsiveness |
| url | https://doi.org/10.1038/s41598-022-22655-6 |
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