A Simple, Realistic Stochastic Model of Gastric Emptying.
Several models of Gastric Emptying (GE) have been employed in the past to represent the rate of delivery of stomach contents to the duodenum and jejunum. These models have all used a deterministic form (algebraic equations or ordinary differential equations), considering GE as a continuous, smooth p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4825969?pdf=render |
| _version_ | 1818505960794095616 |
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| author | Jiraphat Yokrattanasak Andrea De Gaetano Simona Panunzi Pairote Satiracoo Wayne M Lawton Yongwimon Lenbury |
| author_facet | Jiraphat Yokrattanasak Andrea De Gaetano Simona Panunzi Pairote Satiracoo Wayne M Lawton Yongwimon Lenbury |
| author_sort | Jiraphat Yokrattanasak |
| collection | DOAJ |
| description | Several models of Gastric Emptying (GE) have been employed in the past to represent the rate of delivery of stomach contents to the duodenum and jejunum. These models have all used a deterministic form (algebraic equations or ordinary differential equations), considering GE as a continuous, smooth process in time. However, GE is known to occur as a sequence of spurts, irregular both in size and in timing. Hence, we formulate a simple stochastic process model, able to represent the irregular decrements of gastric contents after a meal. The model is calibrated on existing literature data and provides consistent predictions of the observed variability in the emptying trajectories. This approach may be useful in metabolic modeling, since it describes well and explains the apparently heterogeneous GE experimental results in situations where common gastric mechanics across subjects would be expected. |
| first_indexed | 2024-12-10T21:57:58Z |
| format | Article |
| id | doaj.art-f6b25eba18654ba881165520286fd4f7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T21:57:58Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f6b25eba18654ba881165520286fd4f72022-12-22T01:32:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015329710.1371/journal.pone.0153297A Simple, Realistic Stochastic Model of Gastric Emptying.Jiraphat YokrattanasakAndrea De GaetanoSimona PanunziPairote SatiracooWayne M LawtonYongwimon LenburySeveral models of Gastric Emptying (GE) have been employed in the past to represent the rate of delivery of stomach contents to the duodenum and jejunum. These models have all used a deterministic form (algebraic equations or ordinary differential equations), considering GE as a continuous, smooth process in time. However, GE is known to occur as a sequence of spurts, irregular both in size and in timing. Hence, we formulate a simple stochastic process model, able to represent the irregular decrements of gastric contents after a meal. The model is calibrated on existing literature data and provides consistent predictions of the observed variability in the emptying trajectories. This approach may be useful in metabolic modeling, since it describes well and explains the apparently heterogeneous GE experimental results in situations where common gastric mechanics across subjects would be expected.http://europepmc.org/articles/PMC4825969?pdf=render |
| spellingShingle | Jiraphat Yokrattanasak Andrea De Gaetano Simona Panunzi Pairote Satiracoo Wayne M Lawton Yongwimon Lenbury A Simple, Realistic Stochastic Model of Gastric Emptying. PLoS ONE |
| title | A Simple, Realistic Stochastic Model of Gastric Emptying. |
| title_full | A Simple, Realistic Stochastic Model of Gastric Emptying. |
| title_fullStr | A Simple, Realistic Stochastic Model of Gastric Emptying. |
| title_full_unstemmed | A Simple, Realistic Stochastic Model of Gastric Emptying. |
| title_short | A Simple, Realistic Stochastic Model of Gastric Emptying. |
| title_sort | simple realistic stochastic model of gastric emptying |
| url | http://europepmc.org/articles/PMC4825969?pdf=render |
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