Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution
In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution (MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscop...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087617307900 |
| _version_ | 1831517625527566336 |
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| author | Haslet Eksi-Kocak Sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkı Boyaci Ugur Tamer |
| author_facet | Haslet Eksi-Kocak Sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkı Boyaci Ugur Tamer |
| author_sort | Haslet Eksi-Kocak |
| collection | DOAJ |
| description | In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution (MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm−1 versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated. Keywords: Raman mapping, Multivariate curve resolution, FT-Raman spectroscopy, Salicylic acid |
| first_indexed | 2024-12-11T12:04:44Z |
| format | Article |
| id | doaj.art-f6b33d5970a1435d864c4c0b99d46ee8 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-11T12:04:44Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f6b33d5970a1435d864c4c0b99d46ee82022-12-22T01:07:58ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762018-03-01132155162Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolutionHaslet Eksi-Kocak0Sibel Ilbasmis Tamer1Sebnem Yilmaz2Merve Eryilmaz3Ismail Hakkı Boyaci4Ugur Tamer5Department of Biomedical Engineering, Faculty of Engineering, Istanbul Aydin University, Istanbul 34295, TurkeyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering, Istanbul Aydin University, Istanbul 34295, Turkey; Food Research Center, Hacettepe University, Beytepe, Ankara 06800, TurkeyDepartment of Analytical Chemistry, Faculty of Pharmacy, Gazi University, Etiler, Ankara 06330, Turkey; Corresponding author. Faculty of Pharmacy, Department of Analytical Chemistry, Gazi University, Besevler, Ankara 06330, Turkey. Tel.: +90 312 202 31 10.In this study, we proposed a rapid and sensitive method for quantification and spatial distribution of salicylic acid in film tablets using FT-Raman spectroscopy with multivariate curve resolution (MCR). For this purpose, the constituents of film tablets were identified by using FT-Raman spectroscopy, and then eight different concentrations of salicylic acid tablets were visualized by Raman mapping. MCR was applied to mapping data to expose the active pharmaceutical ingredients in the presence of other excipients by monitoring distribution maps and combination of FT-Raman mapping with MCR enabled the determination of lower salicylic acid concentrations. In addition, the distribution of major excipient, lactose, was examined in the tablet form. A calibration curve was obtained by plotting the intensity of the Raman signal at 1635 cm−1 versus the concentration of salicylic acid and the correlation was found to be linear within the range of 0.5%–3.9% with a correlation coefficient of 0.99. The limit of detection for the technique was determined 0.35%. The ability of the technique to quantify salicylic acid in tablet test samples was also investigated. Keywords: Raman mapping, Multivariate curve resolution, FT-Raman spectroscopy, Salicylic acidhttp://www.sciencedirect.com/science/article/pii/S1818087617307900 |
| spellingShingle | Haslet Eksi-Kocak Sibel Ilbasmis Tamer Sebnem Yilmaz Merve Eryilmaz Ismail Hakkı Boyaci Ugur Tamer Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution Asian Journal of Pharmaceutical Sciences |
| title | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution |
| title_full | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution |
| title_fullStr | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution |
| title_full_unstemmed | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution |
| title_short | Quantification and spatial distribution of salicylic acid in film tablets using FT-Raman mapping with multivariate curve resolution |
| title_sort | quantification and spatial distribution of salicylic acid in film tablets using ft raman mapping with multivariate curve resolution |
| url | http://www.sciencedirect.com/science/article/pii/S1818087617307900 |
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