Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species
Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a sui...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/4/805 |
| _version_ | 1827695459318104064 |
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| author | Sandra Martínez-Turiño María Calvo Leonor Cecilia Bedoya Mingmin Zhao Juan Antonio García |
| author_facet | Sandra Martínez-Turiño María Calvo Leonor Cecilia Bedoya Mingmin Zhao Juan Antonio García |
| author_sort | Sandra Martínez-Turiño |
| collection | DOAJ |
| description | Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus <i>Plum pox virus</i> (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a <i>Nicotiana clevelandii</i>-adapted virus, emerged during adaptation to the bridge-host <i>Arabidopsis thaliana</i>, drastically prompted partial adaptation to <i>Chenopodium foetidum</i>. Although both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it. |
| first_indexed | 2024-03-10T12:25:38Z |
| format | Article |
| id | doaj.art-f6b36b19f3ce435c87ee805ba05f5ee9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T12:25:38Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-f6b36b19f3ce435c87ee805ba05f5ee92023-11-21T15:04:43ZengMDPI AGMicroorganisms2076-26072021-04-019480510.3390/microorganisms9040805Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant SpeciesSandra Martínez-Turiño0María Calvo1Leonor Cecilia Bedoya2Mingmin Zhao3Juan Antonio García4Department of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, 28049 Madrid, SpainDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, 28049 Madrid, SpainDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, 28049 Madrid, SpainDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, 28049 Madrid, SpainDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, 28049 Madrid, SpainUnderstanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus <i>Plum pox virus</i> (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a <i>Nicotiana clevelandii</i>-adapted virus, emerged during adaptation to the bridge-host <i>Arabidopsis thaliana</i>, drastically prompted partial adaptation to <i>Chenopodium foetidum</i>. Although both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it.https://www.mdpi.com/2076-2607/9/4/805host jumpingviral evolutiontrade-offplant virusRNA viruspotyvirus |
| spellingShingle | Sandra Martínez-Turiño María Calvo Leonor Cecilia Bedoya Mingmin Zhao Juan Antonio García Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species Microorganisms host jumping viral evolution trade-off plant virus RNA virus potyvirus |
| title | Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species |
| title_full | Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species |
| title_fullStr | Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species |
| title_full_unstemmed | Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species |
| title_short | Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species |
| title_sort | virus host jumping can be boosted by adaptation to a bridge plant species |
| topic | host jumping viral evolution trade-off plant virus RNA virus potyvirus |
| url | https://www.mdpi.com/2076-2607/9/4/805 |
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