Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators

Abstract Background We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms of viral escape from this promising class of HIV-1 entry inhibitors. Res...

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Bibliographic Details
Main Authors: Shiyu Zhang, Andrew P. Holmes, Alexej Dick, Adel A. Rashad, Lucía Enríquez Rodríguez, Gabriela A. Canziani, Michael J. Root, Irwin M. Chaiken
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Retrovirology
Subjects:
HIV-1
Envelope glycoproteins
Entry inhibitor
Resistance mechanism
gp120 shedding
Virus escape
Online Access:https://doi.org/10.1186/s12977-021-00575-z

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