Sites of metastasis and overall survival in esophageal cancer: a population-based study
San-Gang Wu,1,* Wen-Wen Zhang,2,* Zhen-Yu He,2 Jia-Yuan Sun,2 Yong-Xiong Chen,3 Ling Guo4 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laborato...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-12-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/sites-of-metastasis-and-overall-survival-in-esophageal-cancer-a-popula-peer-reviewed-article-CMAR |
| _version_ | 1811192423542423552 |
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| author | Wu SG Zhang WW He ZY Sun JY Chen YX Guo L |
| author_facet | Wu SG Zhang WW He ZY Sun JY Chen YX Guo L |
| author_sort | Wu SG |
| collection | DOAJ |
| description | San-Gang Wu,1,* Wen-Wen Zhang,2,* Zhen-Yu He,2 Jia-Yuan Sun,2 Yong-Xiong Chen,3 Ling Guo4 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 3Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen, 4Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China *These authors contributed equally to this work. Background: There are few population-based studies of the sites of distant metastasis (DM) and survival from esophageal cancer (EC). The aim of this study was to assess the patterns and survival outcomes for site-specific DM from EC using a population-based approach.Methods: Patients diagnosed with de novo stage IV EC between 2010 and 2014 were identified from the Surveillance, Epidemiology, and End Results program database. Overall survival (OS) was compared according to the site of DM.Results: We included 3218 patients in this study; the most common site of DM was the liver, followed by distant lymph nodes, lung, bone and brain. Median OS for patients with liver, distant lymph node, lung, bone, and brain metastases was 5, 10, 6, 4, and 6 months, respectively (p<0.001). Site and number of distant metastases were independent prognostic factors for OS. In patients with a single site of DM, using liver metastases as reference, OS was lower for bone metastases (p=0.026) and higher for distant lymph node metastases (p=0.008), while brain (p=0.653) or lung (p=0.081) metastases had similar OS compared with liver metastases. Similar site-specific survival differences were observed in the subgroup with esophageal adenocarcinoma. However, distant lymph node metastases was associated with better survival (p=0.002) compared to liver, bone, or lung metastases in esophageal squamous cell carcinoma.Conclusion: Site of metastasis affects survival in metastatic EC; OS was worst for bone metastases and greatest for distant lymph node metastases. Keywords: esophageal cancer, SEER, bone metastases, liver metastases, lung metastases, brain metastases |
| first_indexed | 2024-04-11T23:53:34Z |
| format | Article |
| id | doaj.art-f6b52b952a0249d1948fe26ef576d223 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-11T23:53:34Z |
| publishDate | 2017-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-f6b52b952a0249d1948fe26ef576d2232022-12-22T03:56:26ZengDove Medical PressCancer Management and Research1179-13222017-12-01Volume 978178835887Sites of metastasis and overall survival in esophageal cancer: a population-based studyWu SGZhang WWHe ZYSun JYChen YXGuo LSan-Gang Wu,1,* Wen-Wen Zhang,2,* Zhen-Yu He,2 Jia-Yuan Sun,2 Yong-Xiong Chen,3 Ling Guo4 1Department of Radiation Oncology, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Xiamen, 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, 3Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Medical College, Xiamen University, Xiamen, 4Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, People’s Republic of China *These authors contributed equally to this work. Background: There are few population-based studies of the sites of distant metastasis (DM) and survival from esophageal cancer (EC). The aim of this study was to assess the patterns and survival outcomes for site-specific DM from EC using a population-based approach.Methods: Patients diagnosed with de novo stage IV EC between 2010 and 2014 were identified from the Surveillance, Epidemiology, and End Results program database. Overall survival (OS) was compared according to the site of DM.Results: We included 3218 patients in this study; the most common site of DM was the liver, followed by distant lymph nodes, lung, bone and brain. Median OS for patients with liver, distant lymph node, lung, bone, and brain metastases was 5, 10, 6, 4, and 6 months, respectively (p<0.001). Site and number of distant metastases were independent prognostic factors for OS. In patients with a single site of DM, using liver metastases as reference, OS was lower for bone metastases (p=0.026) and higher for distant lymph node metastases (p=0.008), while brain (p=0.653) or lung (p=0.081) metastases had similar OS compared with liver metastases. Similar site-specific survival differences were observed in the subgroup with esophageal adenocarcinoma. However, distant lymph node metastases was associated with better survival (p=0.002) compared to liver, bone, or lung metastases in esophageal squamous cell carcinoma.Conclusion: Site of metastasis affects survival in metastatic EC; OS was worst for bone metastases and greatest for distant lymph node metastases. Keywords: esophageal cancer, SEER, bone metastases, liver metastases, lung metastases, brain metastaseshttps://www.dovepress.com/sites-of-metastasis-and-overall-survival-in-esophageal-cancer-a-popula-peer-reviewed-article-CMAREsophageal cancerSEERbone metastasesliver metastaseslung metastasesbrain metastases |
| spellingShingle | Wu SG Zhang WW He ZY Sun JY Chen YX Guo L Sites of metastasis and overall survival in esophageal cancer: a population-based study Cancer Management and Research Esophageal cancer SEER bone metastases liver metastases lung metastases brain metastases |
| title | Sites of metastasis and overall survival in esophageal cancer: a population-based study |
| title_full | Sites of metastasis and overall survival in esophageal cancer: a population-based study |
| title_fullStr | Sites of metastasis and overall survival in esophageal cancer: a population-based study |
| title_full_unstemmed | Sites of metastasis and overall survival in esophageal cancer: a population-based study |
| title_short | Sites of metastasis and overall survival in esophageal cancer: a population-based study |
| title_sort | sites of metastasis and overall survival in esophageal cancer a population based study |
| topic | Esophageal cancer SEER bone metastases liver metastases lung metastases brain metastases |
| url | https://www.dovepress.com/sites-of-metastasis-and-overall-survival-in-esophageal-cancer-a-popula-peer-reviewed-article-CMAR |
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