Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death.

The Pseudomonas aeruginosa toxin ExoS, secreted by the type III secretion system (T3SS), supports intracellular persistence via its ADP-ribosyltransferase (ADPr) activity. For epithelial cells, this involves inhibiting vacuole acidification, promoting vacuolar escape, countering autophagy, and niche...

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Bibliographic Details
Main Authors: Abby R Kroken, Naren Gajenthra Kumar, Timothy L Yahr, Benjamin E Smith, Vincent Nieto, Hart Horneman, David J Evans, Suzanne M J Fleiszig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010306

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