A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer
Fluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluo...
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MDPI AG
2022-01-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/2/52 |
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| author | Elizaveta I. Kozlikina Kanamat T. Efendiev Andrey Yu. Grigoriev Olesia Y. Bogdanova Igor S. Trifonov Vladimir V. Krylov Victor B. Loschenov |
| author_facet | Elizaveta I. Kozlikina Kanamat T. Efendiev Andrey Yu. Grigoriev Olesia Y. Bogdanova Igor S. Trifonov Vladimir V. Krylov Victor B. Loschenov |
| author_sort | Elizaveta I. Kozlikina |
| collection | DOAJ |
| description | Fluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluorescence-guided resection of pituitary adenomas. The study’s clinical part involved two patients diagnosed with hormonally inactive pituitary macroadenomas and one patient with a hormonally active one. All neoplasms had different sizes and growth patterns. The data showed accumulation of chlorin e6 in tumor tissues in high concentrations: Patient 1: 2 mg/kg, Patient 2: 5 mg/kg, and Patient 3: 4 mg/kg. For Patient 1, the residual part of the tumor was not resected since it was intimately attached to the anterior genu of the internal carotid artery. For Patients 2 and 3, no regions of increased Ce6 accumulation were detected in the tumor foci after resection. Therefore, the use of the Ce6 and a two-channel video system helped to achieve a high degree of tumor resection in each case. |
| first_indexed | 2024-03-09T22:36:18Z |
| format | Article |
| id | doaj.art-f6b5ef3c59af49e39b90fa37f6ae778d |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T22:36:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-f6b5ef3c59af49e39b90fa37f6ae778d2023-11-23T18:48:22ZengMDPI AGBioengineering2306-53542022-01-01925210.3390/bioengineering9020052A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 PhotosensitizerElizaveta I. Kozlikina0Kanamat T. Efendiev1Andrey Yu. Grigoriev2Olesia Y. Bogdanova3Igor S. Trifonov4Vladimir V. Krylov5Victor B. Loschenov6Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, RussiaFederal State Budgetary Educational Institution of Higher Education “A.I. Evdokimov Moscow State University of Medicine and Dentistry”, The Ministry of Healthcare of the Russian Federation, 127473 Moscow, RussiaFederal State Budgetary Educational Institution of Higher Education “A.I. Evdokimov Moscow State University of Medicine and Dentistry”, The Ministry of Healthcare of the Russian Federation, 127473 Moscow, RussiaFederal State Budgetary Educational Institution of Higher Education “A.I. Evdokimov Moscow State University of Medicine and Dentistry”, The Ministry of Healthcare of the Russian Federation, 127473 Moscow, RussiaFederal State Budgetary Educational Institution of Higher Education “A.I. Evdokimov Moscow State University of Medicine and Dentistry”, The Ministry of Healthcare of the Russian Federation, 127473 Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, RussiaFluorescence diagnostics is one of the promising methods for intraoperative detection of brain tumor boundaries and helps in maximizing the extent of resection. This paper presents the results of a pilot study on the first use of the chlorin e6 photosensitizer and a two-channel video system for fluorescence-guided resection of pituitary adenomas. The study’s clinical part involved two patients diagnosed with hormonally inactive pituitary macroadenomas and one patient with a hormonally active one. All neoplasms had different sizes and growth patterns. The data showed accumulation of chlorin e6 in tumor tissues in high concentrations: Patient 1: 2 mg/kg, Patient 2: 5 mg/kg, and Patient 3: 4 mg/kg. For Patient 1, the residual part of the tumor was not resected since it was intimately attached to the anterior genu of the internal carotid artery. For Patients 2 and 3, no regions of increased Ce6 accumulation were detected in the tumor foci after resection. Therefore, the use of the Ce6 and a two-channel video system helped to achieve a high degree of tumor resection in each case.https://www.mdpi.com/2306-5354/9/2/52fluorescence diagnosticspituitary adenomaphotosensitizerchlorin e6 |
| spellingShingle | Elizaveta I. Kozlikina Kanamat T. Efendiev Andrey Yu. Grigoriev Olesia Y. Bogdanova Igor S. Trifonov Vladimir V. Krylov Victor B. Loschenov A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer Bioengineering fluorescence diagnostics pituitary adenoma photosensitizer chlorin e6 |
| title | A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer |
| title_full | A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer |
| title_fullStr | A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer |
| title_full_unstemmed | A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer |
| title_short | A Pilot Study of Fluorescence-Guided Resection of Pituitary Adenomas with Chlorin e6 Photosensitizer |
| title_sort | pilot study of fluorescence guided resection of pituitary adenomas with chlorin e6 photosensitizer |
| topic | fluorescence diagnostics pituitary adenoma photosensitizer chlorin e6 |
| url | https://www.mdpi.com/2306-5354/9/2/52 |
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