The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses

The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses

The Eurasian avian-like swine (EA) H1N1 virus has affected the Chinese swine industry, and human infection cases have been reported occasionally. However, little is known about the pathogenic mechanism of EA H1N1 virus. In this study, we compared the mouse pathogenicity of A/swine/Guangdong/YJ4/2014...

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Bibliographic Details
Main Authors: Mengkai Cai, Ruting Zhong, Chenxiao Qin, Zhiqing Yu, Xiaoyan Wen, Junsi Xian, Yongjie Chen, Yu Cai, Heyou Yi, Lang Gong, Guihong Zhang
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
eurasian avian-like h1n1 swine influenza viruses
<i>pb2</i> gene
pb2-r251k
pathogenicity
polymerase
Online Access:https://www.mdpi.com/1999-4915/12/1/52

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