Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus

Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus

Mutations in Inverted Formin 2 (INF2), a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth Disease (CMT) in humans. In addition to directly remodeling actin filaments in vitro, we have shown that INF2...

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Bibliographic Details
Main Authors: Hua Sun, Khaldoun I. Al-Romaih, Calum A. MacRae, Martin R. Pollak
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:EBioMedicine
Subjects:
INF2
Glomerulus
Rho
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396414000334

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