Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy
Naomi Hayashi,1 Yasuyoshi Sato,1 Yu Fujiwara,1,2 Naoki Fukuda,1 Xiaofei Wang,1 Kenji Nakano,1 Testuya Urasaki,1 Akihiro Ohmoto,1 Makiko Ono,1 Junichi Tomomatsu,1 Yukiko Sato,3 Hiroki Mitani,4 Takashi Toshiyasu,5 Shunji Takahashi1 1Department of Medical Oncology, The Cancer Institute Hospital of Japa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-11-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/clinical-impact-of-cachexia-in-head-and-neck-cancer-patients-who-recei-peer-reviewed-fulltext-article-CMAR |
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| author | Hayashi N Sato Y Fujiwara Y Fukuda N Wang X Nakano K Urasaki T Ohmoto A Ono M Tomomatsu J Sato Y Mitani H Toshiyasu T Takahashi S |
| author_facet | Hayashi N Sato Y Fujiwara Y Fukuda N Wang X Nakano K Urasaki T Ohmoto A Ono M Tomomatsu J Sato Y Mitani H Toshiyasu T Takahashi S |
| author_sort | Hayashi N |
| collection | DOAJ |
| description | Naomi Hayashi,1 Yasuyoshi Sato,1 Yu Fujiwara,1,2 Naoki Fukuda,1 Xiaofei Wang,1 Kenji Nakano,1 Testuya Urasaki,1 Akihiro Ohmoto,1 Makiko Ono,1 Junichi Tomomatsu,1 Yukiko Sato,3 Hiroki Mitani,4 Takashi Toshiyasu,5 Shunji Takahashi1 1Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 2Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York City, NY, USA; 3Pathology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 4Head and Neck Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 5Radiation Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanCorrespondence: Yasuyoshi SatoThe Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto, Tokyo, 135-8550, JapanTel +8135200111Fax +81335200141Email yasuyoshi.sato@jfcr.or.jpPurpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer.Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients.Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of < 4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting.Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemoradiotherapy may improve survival in these patients.Keywords: head and neck cancer, squamous cell carcinoma of head and neck, sarcopenia, cachexia, muscle, skeletal, chemoradiotherapy, prognosis |
| first_indexed | 2024-12-20T04:26:28Z |
| format | Article |
| id | doaj.art-f6ba371db3634bd18c1e7f974d8c232e |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-20T04:26:28Z |
| publishDate | 2021-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-f6ba371db3634bd18c1e7f974d8c232e2022-12-21T19:53:30ZengDove Medical PressCancer Management and Research1179-13222021-11-01Volume 138377838570393Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received ChemoradiotherapyHayashi NSato YFujiwara YFukuda NWang XNakano KUrasaki TOhmoto AOno MTomomatsu JSato YMitani HToshiyasu TTakahashi SNaomi Hayashi,1 Yasuyoshi Sato,1 Yu Fujiwara,1,2 Naoki Fukuda,1 Xiaofei Wang,1 Kenji Nakano,1 Testuya Urasaki,1 Akihiro Ohmoto,1 Makiko Ono,1 Junichi Tomomatsu,1 Yukiko Sato,3 Hiroki Mitani,4 Takashi Toshiyasu,5 Shunji Takahashi1 1Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 2Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, New York City, NY, USA; 3Pathology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 4Head and Neck Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan; 5Radiation Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanCorrespondence: Yasuyoshi SatoThe Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto, Tokyo, 135-8550, JapanTel +8135200111Fax +81335200141Email yasuyoshi.sato@jfcr.or.jpPurpose: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer.Patients and Methods: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients.Results: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of < 4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting.Conclusion: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemoradiotherapy may improve survival in these patients.Keywords: head and neck cancer, squamous cell carcinoma of head and neck, sarcopenia, cachexia, muscle, skeletal, chemoradiotherapy, prognosishttps://www.dovepress.com/clinical-impact-of-cachexia-in-head-and-neck-cancer-patients-who-recei-peer-reviewed-fulltext-article-CMARhead and neck cancersquamous cell carcinoma of head and necksarcopeniacachexiamuscleskeletalchemoradiotherapyprognosis |
| spellingShingle | Hayashi N Sato Y Fujiwara Y Fukuda N Wang X Nakano K Urasaki T Ohmoto A Ono M Tomomatsu J Sato Y Mitani H Toshiyasu T Takahashi S Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy Cancer Management and Research head and neck cancer squamous cell carcinoma of head and neck sarcopenia cachexia muscle skeletal chemoradiotherapy prognosis |
| title | Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy |
| title_full | Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy |
| title_fullStr | Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy |
| title_full_unstemmed | Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy |
| title_short | Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy |
| title_sort | clinical impact of cachexia in head and neck cancer patients who received chemoradiotherapy |
| topic | head and neck cancer squamous cell carcinoma of head and neck sarcopenia cachexia muscle skeletal chemoradiotherapy prognosis |
| url | https://www.dovepress.com/clinical-impact-of-cachexia-in-head-and-neck-cancer-patients-who-recei-peer-reviewed-fulltext-article-CMAR |
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