Effect of the Combination of Everolimus and Mesenchymal Stromal Cells on Regulatory T Cells Levels and in a Liver Transplant Rejection Model in Rats

Effect of the Combination of Everolimus and Mesenchymal Stromal Cells on Regulatory T Cells Levels and in a Liver Transplant Rejection Model in Rats

IntroductionMesenchymal stromal cells (MSCs) have particular properties that are of interest in organ transplantation, including the expansion of regulatory T cells (Tregs), a key factor in transplant tolerance induction. However, the most effective immunosuppressive drug to associate with MSCs has...

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Bibliographic Details
Main Authors: Morgan Vandermeulen, Pauline Erpicum, Noella Bletard, Laurence Poma, François Jouret, Olivier Detry
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
experimental model
cell-therapy
stem cells
mTOR inhibitors
graft tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.877953/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.877953/full

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