Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study
Background/Aims A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise. Methods This study used data from the Korean National Health Insurance Service. Individuals 20–39 years o...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2023-07-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://kjim.org/upload/kjim-2022-405.pdf |
| _version_ | 1797782105640402944 |
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| author | Jinyoung Kim Kyungdo Han Mee Kyoung Kim Ki-Hyun Baek Ki-Ho Song Hyuk-Sang Kwon |
| author_facet | Jinyoung Kim Kyungdo Han Mee Kyoung Kim Ki-Hyun Baek Ki-Ho Song Hyuk-Sang Kwon |
| author_sort | Jinyoung Kim |
| collection | DOAJ |
| description | Background/Aims A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise. Methods This study used data from the Korean National Health Insurance Service. Individuals 20–39 years of age who underwent ≥ 4 health checkups from 2009–2013 were enrolled and followed throughout 2019. To quantify the metabolic burden, groups were divided by the number of diagnoses of metabolic syndrome across four consecutive health examinations. Results Among the study population (n = 1,204,646), 5,929 (0.5%) were diagnosed with thyroid cancer during a follow-up period of 5 years. The hazard ratio (95% confidence interval) values of thyroid cancer occurrence according to the number (1–4) of diagnoses of metabolic syndrome across the four health examinations compared to the group without met-abolic syndrome were significantly greater, as follows: 1.12 (1.02–1.23), 1.25 (1.10–1.42), 1.33 (1.15–1.55), and 1.48 (1.25–1.75) (p for trend < 0.01), respectively. Each component of metabolic syndrome showed a significant increase in hazard ratio according to the number of diagnoses except for impaired fasting glucose criteria. Conclusions Cumulative exposure to metabolic syndrome was associated with thyroid cancer risk in young adults. |
| first_indexed | 2024-03-13T00:06:21Z |
| format | Article |
| id | doaj.art-f6bb5571ff3e4242833e8d0c3613367a |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-03-13T00:06:21Z |
| publishDate | 2023-07-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-f6bb5571ff3e4242833e8d0c3613367a2023-07-13T01:22:49ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482023-07-0138452653310.3904/kjim.2022.405170796Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort studyJinyoung Kim0Kyungdo Han1Mee Kyoung Kim2Ki-Hyun Baek3Ki-Ho Song4Hyuk-Sang Kwon5 Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise. Methods This study used data from the Korean National Health Insurance Service. Individuals 20–39 years of age who underwent ≥ 4 health checkups from 2009–2013 were enrolled and followed throughout 2019. To quantify the metabolic burden, groups were divided by the number of diagnoses of metabolic syndrome across four consecutive health examinations. Results Among the study population (n = 1,204,646), 5,929 (0.5%) were diagnosed with thyroid cancer during a follow-up period of 5 years. The hazard ratio (95% confidence interval) values of thyroid cancer occurrence according to the number (1–4) of diagnoses of metabolic syndrome across the four health examinations compared to the group without met-abolic syndrome were significantly greater, as follows: 1.12 (1.02–1.23), 1.25 (1.10–1.42), 1.33 (1.15–1.55), and 1.48 (1.25–1.75) (p for trend < 0.01), respectively. Each component of metabolic syndrome showed a significant increase in hazard ratio according to the number of diagnoses except for impaired fasting glucose criteria. Conclusions Cumulative exposure to metabolic syndrome was associated with thyroid cancer risk in young adults.http://kjim.org/upload/kjim-2022-405.pdfmetabolic syndromethyroid cancerprevention and control |
| spellingShingle | Jinyoung Kim Kyungdo Han Mee Kyoung Kim Ki-Hyun Baek Ki-Ho Song Hyuk-Sang Kwon Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study The Korean Journal of Internal Medicine metabolic syndrome thyroid cancer prevention and control |
| title | Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study |
| title_full | Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study |
| title_fullStr | Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study |
| title_full_unstemmed | Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study |
| title_short | Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study |
| title_sort | cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults a population based cohort study |
| topic | metabolic syndrome thyroid cancer prevention and control |
| url | http://kjim.org/upload/kjim-2022-405.pdf |
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