Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping
IntroductionPrevious studies have revealed structural, functional, and metabolic changes in brain regions inside the cortico-striatal-thalamo-cortical (CSTC) loop in patients with paroxysmal kinesigenic dyskinesia (PKD), whereas no quantitative susceptibility mapping (QSM)-related studies have explo...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1164600/full |
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| author | Fangfang Xie Ting Mao Jingyi Tang Linmei Zhao Jiuqing Guo Huashan Lin Dongcui Wang Dongcui Wang Gaofeng Zhou Gaofeng Zhou |
| author_facet | Fangfang Xie Ting Mao Jingyi Tang Linmei Zhao Jiuqing Guo Huashan Lin Dongcui Wang Dongcui Wang Gaofeng Zhou Gaofeng Zhou |
| author_sort | Fangfang Xie |
| collection | DOAJ |
| description | IntroductionPrevious studies have revealed structural, functional, and metabolic changes in brain regions inside the cortico-striatal-thalamo-cortical (CSTC) loop in patients with paroxysmal kinesigenic dyskinesia (PKD), whereas no quantitative susceptibility mapping (QSM)-related studies have explored brain iron deposition in these areas.MethodsA total of eight familial PKD patients and 10 of their healthy family members (normal controls) were recruited and underwent QSM on a 3T magnetic resonance imaging system. Magnetic susceptibility maps were reconstructed using a multi-scale dipole inversion algorithm. Thereafter, we specifically analyzed changes in local mean susceptibility values in cortical regions and subcortical nuclei inside the motor CSTC loop.ResultsCompared with normal controls, PKD patients had altered brain iron levels. In the cortical gray matter area involved with the motor CSTC loop, susceptibility values were generally elevated, especially in the bilateral M1 and PMv regions. In the subcortical nuclei regions involved with the motor CSTC loop, susceptibility values were generally lower, especially in the bilateral substantia nigra regions.ConclusionOur results provide new evidence for the neuropathogenesis of PKD and suggest that an imbalance in brain iron levels may play a role in PKD. |
| first_indexed | 2024-03-13T00:58:36Z |
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| id | doaj.art-f6bd5ea9967243fe8ccb0a6bfdcaaae2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T00:58:36Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-f6bd5ea9967243fe8ccb0a6bfdcaaae22023-07-06T14:50:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-07-011410.3389/fneur.2023.11646001164600Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mappingFangfang Xie0Ting Mao1Jingyi Tang2Linmei Zhao3Jiuqing Guo4Huashan Lin5Dongcui Wang6Dongcui Wang7Gaofeng Zhou8Gaofeng Zhou9Department of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Pharmaceutical Diagnosis, GE Healthcare, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaIntroductionPrevious studies have revealed structural, functional, and metabolic changes in brain regions inside the cortico-striatal-thalamo-cortical (CSTC) loop in patients with paroxysmal kinesigenic dyskinesia (PKD), whereas no quantitative susceptibility mapping (QSM)-related studies have explored brain iron deposition in these areas.MethodsA total of eight familial PKD patients and 10 of their healthy family members (normal controls) were recruited and underwent QSM on a 3T magnetic resonance imaging system. Magnetic susceptibility maps were reconstructed using a multi-scale dipole inversion algorithm. Thereafter, we specifically analyzed changes in local mean susceptibility values in cortical regions and subcortical nuclei inside the motor CSTC loop.ResultsCompared with normal controls, PKD patients had altered brain iron levels. In the cortical gray matter area involved with the motor CSTC loop, susceptibility values were generally elevated, especially in the bilateral M1 and PMv regions. In the subcortical nuclei regions involved with the motor CSTC loop, susceptibility values were generally lower, especially in the bilateral substantia nigra regions.ConclusionOur results provide new evidence for the neuropathogenesis of PKD and suggest that an imbalance in brain iron levels may play a role in PKD.https://www.frontiersin.org/articles/10.3389/fneur.2023.1164600/fullparoxysmal kinesigenic dyskinesia (PKD)cortico-striatal-thalamo-cortical loopquantitative susceptibility mapping (QSM)multi-scale dipole inversioniron deposition |
| spellingShingle | Fangfang Xie Ting Mao Jingyi Tang Linmei Zhao Jiuqing Guo Huashan Lin Dongcui Wang Dongcui Wang Gaofeng Zhou Gaofeng Zhou Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping Frontiers in Neurology paroxysmal kinesigenic dyskinesia (PKD) cortico-striatal-thalamo-cortical loop quantitative susceptibility mapping (QSM) multi-scale dipole inversion iron deposition |
| title | Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| title_full | Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| title_fullStr | Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| title_full_unstemmed | Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| title_short | Evaluation of iron deposition in the motor CSTC loop of a Chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| title_sort | evaluation of iron deposition in the motor cstc loop of a chinese family with paroxysmal kinesigenic dyskinesia using quantitative susceptibility mapping |
| topic | paroxysmal kinesigenic dyskinesia (PKD) cortico-striatal-thalamo-cortical loop quantitative susceptibility mapping (QSM) multi-scale dipole inversion iron deposition |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1164600/full |
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