High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma.
PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4642967?pdf=render |
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| author | Yueh-Min Lin Wen-Wei Sung Ming-Ju Hsieh Shih-Chen Tsai Hung-Wen Lai Shu-Mei Yang Ko-Hong Shen Mu-Kuan Chen Huei Lee Kun-Tu Yeh Chih-Jung Chen |
| author_facet | Yueh-Min Lin Wen-Wei Sung Ming-Ju Hsieh Shih-Chen Tsai Hung-Wen Lai Shu-Mei Yang Ko-Hong Shen Mu-Kuan Chen Huei Lee Kun-Tu Yeh Chih-Jung Chen |
| author_sort | Yueh-Min Lin |
| collection | DOAJ |
| description | PD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit. |
| first_indexed | 2024-12-11T21:43:34Z |
| format | Article |
| id | doaj.art-f6c10c88807f412caeeaa890b19b7a24 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T21:43:34Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f6c10c88807f412caeeaa890b19b7a242022-12-22T00:49:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014265610.1371/journal.pone.0142656High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma.Yueh-Min LinWen-Wei SungMing-Ju HsiehShih-Chen TsaiHung-Wen LaiShu-Mei YangKo-Hong ShenMu-Kuan ChenHuei LeeKun-Tu YehChih-Jung ChenPD-L1 has been widely demonstrated to contribute to failed antitumor immunity. Blockade of PD-L1 with monoclonal antibody could modulate the tumor immune environment to augment immunotherapy. PD-L1 expression is also detected in several types of cancer and is associated with poor prognosis. However, the prognostic role of PD-L1 in oral squamous cell carcinoma (OSCC) is still controversial. Our aim was to determine the role of PD-L1 in the prognosis of OSCC patients to identify its potential therapeutic relevance. PD-L1 immunoreactivity was analyzed by immunohistochemistry in 305 cancer specimens from primary OSCC patients. The medium follow-up time after surgery was 3.8 years (range from 0.1 to 11.1 years). The prognostic value of PD-L1 on overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. Higher PD-L1 expression is more likely in tumor tissues of female than male OSCC patients (P = 0.0062). Patients with distant metastasis also had high PD-L1 expression (P = 0.0103). Multivariate analysis identified high PD-L1 expression as an independent risk factor in males and smokers (males: hazard ratio = 1.556, P = 0.0077; smokers: hazard ratio = 2.058, P = 0.0004). We suggest that PD-L1 expression, determined by IHC staining, could be an independent prognostic marker for OSCC patients who are male or who have a smoking habit.http://europepmc.org/articles/PMC4642967?pdf=render |
| spellingShingle | Yueh-Min Lin Wen-Wei Sung Ming-Ju Hsieh Shih-Chen Tsai Hung-Wen Lai Shu-Mei Yang Ko-Hong Shen Mu-Kuan Chen Huei Lee Kun-Tu Yeh Chih-Jung Chen High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. PLoS ONE |
| title | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. |
| title_full | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. |
| title_fullStr | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. |
| title_full_unstemmed | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. |
| title_short | High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma. |
| title_sort | high pd l1 expression correlates with metastasis and poor prognosis in oral squamous cell carcinoma |
| url | http://europepmc.org/articles/PMC4642967?pdf=render |
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