Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ)
Abstract Introduction The Diabetes Injection Device Preference Questionnaire (DID-PQ) was designed to assess patient preference between two non-insulin injection devices. In a recent crossover study, people with type 2 diabetes (T2D) completed the DID-PQ after performing mock injections with two non...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-12-01
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| Series: | Journal of Patient-Reported Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41687-020-00266-x |
| _version_ | 1818646163528613888 |
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| author | Kristina S. Boye Louis S. Matza Brooke M. Currie Karin S. Coyne |
| author_facet | Kristina S. Boye Louis S. Matza Brooke M. Currie Karin S. Coyne |
| author_sort | Kristina S. Boye |
| collection | DOAJ |
| description | Abstract Introduction The Diabetes Injection Device Preference Questionnaire (DID-PQ) was designed to assess patient preference between two non-insulin injection devices. In a recent crossover study, people with type 2 diabetes (T2D) completed the DID-PQ after performing mock injections with two non-insulin injection devices. The purpose of the current analysis was to use these data to assess construct validity of the DID-PQ and demonstrate one way to test whether there is a significant preference for one injection device over another. Methods Data were from an open-label, multicenter, randomized, crossover study assessing preference between the dulaglutide and semaglutide injection pens. In addition to the 10-item DID-PQ, people with T2D completed a global item assessing overall preference. DID-PQ responses were compared to the global preference item (percent agreement, Gwet’s AC1, prevalence-adjusted and bias-adjusted Kappa [PABAK]). For each item of the DID-PQ, a two-sided binomial test assessed whether the difference in preference was statistically significant. Results The sample included 310 participants (48.4% female; mean age = 60.0). The DID-PQ had minimal missing data. There was strong concordance (percent agreement > 78%) between the global preference item and all DID-PQ items except item 6, which assesses preference related to needle size (59.7%). The Gwet AC1 and PABAK statistics also indicated strong agreement between the global preference item and all DID-PQ items except item 6. There was a statistically significant difference (p < 0.0001) in preference on every DID-PQ item, with more participants preferring the dulaglutide device. Discussion Patient preference has been recommended as a “major factor driving the choice of medication” in a consensus report by the American Diabetes Association and the European Association for the Study of Diabetes. Current findings suggest that the DID-PQ may be a useful tool for providing insight into preferences of people with T2D using non-insulin injectable medication. |
| first_indexed | 2024-12-17T00:42:16Z |
| format | Article |
| id | doaj.art-f6c289c6b9264741b4a1cd156260ab5d |
| institution | Directory Open Access Journal |
| issn | 2509-8020 |
| language | English |
| last_indexed | 2024-12-17T00:42:16Z |
| publishDate | 2020-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Patient-Reported Outcomes |
| spelling | doaj.art-f6c289c6b9264741b4a1cd156260ab5d2022-12-21T22:09:59ZengSpringerOpenJournal of Patient-Reported Outcomes2509-80202020-12-01411710.1186/s41687-020-00266-xValidity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ)Kristina S. Boye0Louis S. Matza1Brooke M. Currie2Karin S. Coyne3Eli Lilly and CompanyEvideraEvideraEvideraAbstract Introduction The Diabetes Injection Device Preference Questionnaire (DID-PQ) was designed to assess patient preference between two non-insulin injection devices. In a recent crossover study, people with type 2 diabetes (T2D) completed the DID-PQ after performing mock injections with two non-insulin injection devices. The purpose of the current analysis was to use these data to assess construct validity of the DID-PQ and demonstrate one way to test whether there is a significant preference for one injection device over another. Methods Data were from an open-label, multicenter, randomized, crossover study assessing preference between the dulaglutide and semaglutide injection pens. In addition to the 10-item DID-PQ, people with T2D completed a global item assessing overall preference. DID-PQ responses were compared to the global preference item (percent agreement, Gwet’s AC1, prevalence-adjusted and bias-adjusted Kappa [PABAK]). For each item of the DID-PQ, a two-sided binomial test assessed whether the difference in preference was statistically significant. Results The sample included 310 participants (48.4% female; mean age = 60.0). The DID-PQ had minimal missing data. There was strong concordance (percent agreement > 78%) between the global preference item and all DID-PQ items except item 6, which assesses preference related to needle size (59.7%). The Gwet AC1 and PABAK statistics also indicated strong agreement between the global preference item and all DID-PQ items except item 6. There was a statistically significant difference (p < 0.0001) in preference on every DID-PQ item, with more participants preferring the dulaglutide device. Discussion Patient preference has been recommended as a “major factor driving the choice of medication” in a consensus report by the American Diabetes Association and the European Association for the Study of Diabetes. Current findings suggest that the DID-PQ may be a useful tool for providing insight into preferences of people with T2D using non-insulin injectable medication.https://doi.org/10.1186/s41687-020-00266-xPreferenceInjection devicesType 2 diabetesPatient-reported outcome measuresPRODulaglutide |
| spellingShingle | Kristina S. Boye Louis S. Matza Brooke M. Currie Karin S. Coyne Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) Journal of Patient-Reported Outcomes Preference Injection devices Type 2 diabetes Patient-reported outcome measures PRO Dulaglutide |
| title | Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) |
| title_full | Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) |
| title_fullStr | Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) |
| title_full_unstemmed | Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) |
| title_short | Validity and analysis of the Diabetes Injection Device Preference Questionnaire (DID-PQ) |
| title_sort | validity and analysis of the diabetes injection device preference questionnaire did pq |
| topic | Preference Injection devices Type 2 diabetes Patient-reported outcome measures PRO Dulaglutide |
| url | https://doi.org/10.1186/s41687-020-00266-x |
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