Management of inoperable endometrial cancer
Some endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant treatment before surgery. Radiation therapy alone (of different modes) has been used as t...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2022-07-01
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| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-21219.pdf |
| _version_ | 1828263353242353664 |
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| author | Supakorn Pitakkarnkul Saranya Chanpanitkitchot Siriwan Tangjitgamol |
| author_facet | Supakorn Pitakkarnkul Saranya Chanpanitkitchot Siriwan Tangjitgamol |
| author_sort | Supakorn Pitakkarnkul |
| collection | DOAJ |
| description | Some endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant treatment before surgery. Radiation therapy alone (of different modes) has been used as the sole definitive therapeutic modality, particularly for early-stage disease that is limited to the uterine body and cervix with or without parametrial invasion. The most common treatment modality is neoadjuvant treatment before surgery. Postoperative adjuvant treatment is also occasionally used, depending mainly on the sites of the disease and the results of surgery. Data on neoadjuvant hormonal or radiation therapy are limited, with studies focusing on laboratory outcomes or having only a small number of patients. Most neoadjuvant treatments before surgery involved chemotherapy and fewer combined chemoradiotherapy. Surgery was generally performed, particularly in patients who had shown responses or at least stable disease to neoadjuvant treatment. Perioperative outcomes after neoadjuvant treatment were superior to those after primary surgery, whereas survival data were still inconsistent. Features that had or tended to have a favorable prognosis were younger age, early-stage disease, response to neoadjuvant treatment, low preoperative cancer antigen-125 level, and optimal surgery. Among different modalities of neoadjuvant treatment, which has become a frequent mode of treatment, neoadjuvant chemotherapy was more common than radiation therapy alone or chemoradiation. |
| first_indexed | 2024-04-13T04:10:33Z |
| format | Article |
| id | doaj.art-f6c2b9c2ebe34446973f5086fb7e8a8e |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-04-13T04:10:33Z |
| publishDate | 2022-07-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-f6c2b9c2ebe34446973f5086fb7e8a8e2022-12-22T03:03:07ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802022-07-0165430331610.5468/ogs.212198690Management of inoperable endometrial cancerSupakorn Pitakkarnkul0Saranya Chanpanitkitchot1Siriwan Tangjitgamol2 Division of Gynecologic Oncology, National Cancer Institute, Rangsit University College of Medicine, Bangkok, Thailand Department of Obstetrics and Gynecology, Rajavithi Hospital, Rangsit University College of Medicine, Bangkok, Thailand Women’s Care Center, MedPark Hospital, Navamindradhiraj University, Bangkok, ThailandSome endometrial cancer (EMC) patients are not good candidates for primary surgery. The three major types of treatment for inoperable EMC are radiation therapy, chemotherapy, or their combination as neoadjuvant treatment before surgery. Radiation therapy alone (of different modes) has been used as the sole definitive therapeutic modality, particularly for early-stage disease that is limited to the uterine body and cervix with or without parametrial invasion. The most common treatment modality is neoadjuvant treatment before surgery. Postoperative adjuvant treatment is also occasionally used, depending mainly on the sites of the disease and the results of surgery. Data on neoadjuvant hormonal or radiation therapy are limited, with studies focusing on laboratory outcomes or having only a small number of patients. Most neoadjuvant treatments before surgery involved chemotherapy and fewer combined chemoradiotherapy. Surgery was generally performed, particularly in patients who had shown responses or at least stable disease to neoadjuvant treatment. Perioperative outcomes after neoadjuvant treatment were superior to those after primary surgery, whereas survival data were still inconsistent. Features that had or tended to have a favorable prognosis were younger age, early-stage disease, response to neoadjuvant treatment, low preoperative cancer antigen-125 level, and optimal surgery. Among different modalities of neoadjuvant treatment, which has become a frequent mode of treatment, neoadjuvant chemotherapy was more common than radiation therapy alone or chemoradiation.http://ogscience.org/upload/pdf/ogs-21219.pdfendometrial cancerradiotherapychemotherapyquality of life |
| spellingShingle | Supakorn Pitakkarnkul Saranya Chanpanitkitchot Siriwan Tangjitgamol Management of inoperable endometrial cancer Obstetrics & Gynecology Science endometrial cancer radiotherapy chemotherapy quality of life |
| title | Management of inoperable endometrial cancer |
| title_full | Management of inoperable endometrial cancer |
| title_fullStr | Management of inoperable endometrial cancer |
| title_full_unstemmed | Management of inoperable endometrial cancer |
| title_short | Management of inoperable endometrial cancer |
| title_sort | management of inoperable endometrial cancer |
| topic | endometrial cancer radiotherapy chemotherapy quality of life |
| url | http://ogscience.org/upload/pdf/ogs-21219.pdf |
| work_keys_str_mv | AT supakornpitakkarnkul managementofinoperableendometrialcancer AT saranyachanpanitkitchot managementofinoperableendometrialcancer AT siriwantangjitgamol managementofinoperableendometrialcancer |