Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms
Shikonin, the primary active compound found in the rhizome of the traditional Chinese medicinal herb known as “ZiCao”, exhibits a diverse range of pharmacological effects. This drug has a wide range of uses, including as an anti-inflammatory, antioxidant, and anti-cancer agent. It is also effective...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223009290 |
| _version_ | 1797744101931614208 |
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| author | Yimeng Guo Mingming Zhou Zhenzhen Mu Jinrong Guo Yuzhu Hou Yuanyuan Xu Long Geng |
| author_facet | Yimeng Guo Mingming Zhou Zhenzhen Mu Jinrong Guo Yuzhu Hou Yuanyuan Xu Long Geng |
| author_sort | Yimeng Guo |
| collection | DOAJ |
| description | Shikonin, the primary active compound found in the rhizome of the traditional Chinese medicinal herb known as “ZiCao”, exhibits a diverse range of pharmacological effects. This drug has a wide range of uses, including as an anti-inflammatory, antioxidant, and anti-cancer agent. It is also effective in promoting wound healing and treating autoimmune diseases such as multiple sclerosis, diabetes, asthma, systemic lupus erythematosus, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. Although shikonin has a wide range of applications, its mechanisms are still not fully understood. This review article provides a comprehensive overview of the recent advancements in the use of shikonin for the treatment of immune-related diseases. The article also delves into the anti-inflammatory and immunoregulatory mechanisms of shikonin and offers insights into the inflammation and immunopathogenesis of related diseases. Overall, this article serves as a valuable resource for researchers and clinicians working in this field. These findings not only provide significant new information on the effects and mechanisms of shikonin but also establish a foundation for the development of clinical applications in treating autoimmune diseases. |
| first_indexed | 2024-03-12T15:04:55Z |
| format | Article |
| id | doaj.art-f6c4910168c94ccab187399bca6c30f9 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:04:55Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f6c4910168c94ccab187399bca6c30f92023-08-13T04:52:44ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115138Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanismsYimeng Guo0Mingming Zhou1Zhenzhen Mu2Jinrong Guo3Yuzhu Hou4Yuanyuan Xu5Long Geng6Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, ChinaDepartment of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, ChinaDepartment of Dermatology, Shengjing Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, ChinaDepartment of Dermatology, Jincheng People’s Hospital, 456N Wenchang East Street, Jincheng, Shanxi 048000, ChinaDepartment of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, ChinaDepartment of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, ChinaDepartment of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, China; Corresponding author at: Department of Dermatology, The First Hospital of China Medical University, 155N Nanjing Street, Heping District, Shenyang, Liaoning 110000, China.Shikonin, the primary active compound found in the rhizome of the traditional Chinese medicinal herb known as “ZiCao”, exhibits a diverse range of pharmacological effects. This drug has a wide range of uses, including as an anti-inflammatory, antioxidant, and anti-cancer agent. It is also effective in promoting wound healing and treating autoimmune diseases such as multiple sclerosis, diabetes, asthma, systemic lupus erythematosus, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. Although shikonin has a wide range of applications, its mechanisms are still not fully understood. This review article provides a comprehensive overview of the recent advancements in the use of shikonin for the treatment of immune-related diseases. The article also delves into the anti-inflammatory and immunoregulatory mechanisms of shikonin and offers insights into the inflammation and immunopathogenesis of related diseases. Overall, this article serves as a valuable resource for researchers and clinicians working in this field. These findings not only provide significant new information on the effects and mechanisms of shikonin but also establish a foundation for the development of clinical applications in treating autoimmune diseases.http://www.sciencedirect.com/science/article/pii/S0753332223009290Traditional Chinese medicineShikoninAnti-inflammation and immune regulationImmune-associated inflammatory diseases |
| spellingShingle | Yimeng Guo Mingming Zhou Zhenzhen Mu Jinrong Guo Yuzhu Hou Yuanyuan Xu Long Geng Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms Biomedicine & Pharmacotherapy Traditional Chinese medicine Shikonin Anti-inflammation and immune regulation Immune-associated inflammatory diseases |
| title | Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms |
| title_full | Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms |
| title_fullStr | Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms |
| title_full_unstemmed | Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms |
| title_short | Recent advances in shikonin for the treatment of immune-related diseases: Anti-inflammatory and immunomodulatory mechanisms |
| title_sort | recent advances in shikonin for the treatment of immune related diseases anti inflammatory and immunomodulatory mechanisms |
| topic | Traditional Chinese medicine Shikonin Anti-inflammation and immune regulation Immune-associated inflammatory diseases |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223009290 |
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