Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules
Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/3/1119 |
| _version_ | 1797623800296112128 |
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| author | Xingran Kou Xinping Zhang Ying Cheng Miao Yu Qingran Meng Qinfei Ke |
| author_facet | Xingran Kou Xinping Zhang Ying Cheng Miao Yu Qingran Meng Qinfei Ke |
| author_sort | Xingran Kou |
| collection | DOAJ |
| description | Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO<sub>2</sub>), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO<sub>2</sub> reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface. |
| first_indexed | 2024-03-11T09:33:53Z |
| format | Article |
| id | doaj.art-f6c5515ac0234572ae3e6899e1543097 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:33:53Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f6c5515ac0234572ae3e6899e15430972023-11-16T17:27:55ZengMDPI AGMolecules1420-30492023-01-01283111910.3390/molecules28031119Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin MicrocapsulesXingran Kou0Xinping Zhang1Ying Cheng2Miao Yu3Qingran Meng4Qinfei Ke5Collaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaCollaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaCollaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaCollaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaCollaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaCollaborative Innovation Center of Fragrance Flavor and Cosmetics, School of Perfume and Aroma Technology, Shanghai Research Institute of Fragrance & Flavour Industry, Shanghai Institute of Technology, Shanghai 201418, ChinaAgglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO<sub>2</sub>), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flowability and lower hygroscopicity and exhibited good anticaking properties. Mechanism research revealed that CaSt, MgSt, and SiO<sub>2</sub> reduce hygroscopicity and caking by increasing the glass transition temperature of the microcapsules, while MAN prevents the hydroxyl group of HP-β-CD from combining with water molecules in the air by a crystal outer-layer on the microcapsule surface.https://www.mdpi.com/1420-3049/28/3/1119spray dryingmicrocapsulesmannitolcrystallisationcaking |
| spellingShingle | Xingran Kou Xinping Zhang Ying Cheng Miao Yu Qingran Meng Qinfei Ke Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules Molecules spray drying microcapsules mannitol crystallisation caking |
| title | Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules |
| title_full | Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules |
| title_fullStr | Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules |
| title_full_unstemmed | Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules |
| title_short | Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules |
| title_sort | mannitol is a good anticaking agent for spray dried hydroxypropyl beta cyclodextrin microcapsules |
| topic | spray drying microcapsules mannitol crystallisation caking |
| url | https://www.mdpi.com/1420-3049/28/3/1119 |
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