Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats
Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Swedish Nutrition Foundation
2022-10-01
|
| Series: | Food & Nutrition Research |
| Subjects: | |
| Online Access: | https://foodandnutritionresearch.net/index.php/fnr/article/view/8708/14911 |
| _version_ | 1817977756126806016 |
|---|---|
| author | Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen |
| author_facet | Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen |
| author_sort | Iselin Vildmyren |
| collection | DOAJ |
| description | Background: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from Atlantic cod (Gadus morhua) filleting on the development of high blood pressure in obese Zucker fa/fa rats, which spontaneously develop hypertension and proteinuria. The secondary objectives were to investigate any changes in kidney morphology, kidney function and organ damage, and to determine the potential inhibition of cod residuals on renin and angiotensin-converting enzyme (ACE) activities in vitro. Methods: Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically. Results: The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups. Conclusion: A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage. |
| first_indexed | 2024-04-13T22:20:33Z |
| format | Article |
| id | doaj.art-f6c7551947054d60b1849a9282cca923 |
| institution | Directory Open Access Journal |
| issn | 1654-661X |
| language | English |
| last_indexed | 2024-04-13T22:20:33Z |
| publishDate | 2022-10-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj.art-f6c7551947054d60b1849a9282cca9232022-12-22T02:27:17ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2022-10-016611110.29219/fnr.v66.87088708Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa ratsIselin Vildmyren0Åge Oterhals1Sabine Leh2Tor Andreas Samuelsen3Alfred Halstensen4Hans-Peter Marti5Oddrun Anita Gudbrandsen6Dietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, Bergen, NorwayNofima, Bergen, NorwayDepartment of Pathology, Haukeland University Hospital, Bergen, NorwayNofima, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, NorwayDietary Protein Research Group, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital, Bergen, NorwayBackground: Documentation of health effects of residuals after fish filleting may motivate both consumers and producers to increase the use of this under-utilised protein source. Objectives: The primary objective of the present study was to investigate the effects of a diet containing residuals from Atlantic cod (Gadus morhua) filleting on the development of high blood pressure in obese Zucker fa/fa rats, which spontaneously develop hypertension and proteinuria. The secondary objectives were to investigate any changes in kidney morphology, kidney function and organ damage, and to determine the potential inhibition of cod residuals on renin and angiotensin-converting enzyme (ACE) activities in vitro. Methods: Male rats were fed diets containing protein powder prepared from head, backbone and skin fraction (HBS, n = 6) from Atlantic cod as 25% of total protein with the remaining 75% as casein, or casein as the sole protein source (Control group, n = 6) for 4 weeks. Blood pressure was measured on day 0, 14 and 26. Kidneys were analysed morphologically, and markers for renal function and organ damage were analysed biochemically. Results: The HBS diet attenuated the blood pressure increase compared to the Control group, but kidney damage and dysfunction were similar between the two groups. Conclusion: A diet containing a protein powder consisting of HBS fraction from cod attenuated the blood pressure increase in obese Zucker fa/fa rats, without preventing kidney damage.https://foodandnutritionresearch.net/index.php/fnr/article/view/8708/14911fish proteinsfish residualsblood pressurehypertensionkidneyobesity |
| spellingShingle | Iselin Vildmyren Åge Oterhals Sabine Leh Tor Andreas Samuelsen Alfred Halstensen Hans-Peter Marti Oddrun Anita Gudbrandsen Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats Food & Nutrition Research fish proteins fish residuals blood pressure hypertension kidney obesity |
| title | Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
| title_full | Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
| title_fullStr | Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
| title_full_unstemmed | Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
| title_short | Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats |
| title_sort | intake of residuals from atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese zucker fa fa rats |
| topic | fish proteins fish residuals blood pressure hypertension kidney obesity |
| url | https://foodandnutritionresearch.net/index.php/fnr/article/view/8708/14911 |
| work_keys_str_mv | AT iselinvildmyren intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT ageoterhals intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT sabineleh intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT torandreassamuelsen intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT alfredhalstensen intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT hanspetermarti intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats AT oddrunanitagudbrandsen intakeofresidualsfromatlanticcodattenuatedbloodpressureincreasebutdidnotdelaydevelopmentofkidneydamageinobesezuckerfafarats |