Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill
Ever since 3D printing was introduced to the field of pharmacy, it has caused a paradigm shift from the manufacturing of large-scale to small batches of medicines tailored accordingly to the specific needs of patients. This study aimed to formulate and fabricate two-layered 3D tablets using the digi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2022-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632206674A.pdf |
| _version_ | 1828048907983126528 |
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| author | Adamov Ivana Medarević Đorđe Ivković Branka Ivković Aleksandar Ibrić Svetlana |
| author_facet | Adamov Ivana Medarević Đorđe Ivković Branka Ivković Aleksandar Ibrić Svetlana |
| author_sort | Adamov Ivana |
| collection | DOAJ |
| description | Ever since 3D printing was introduced to the field of pharmacy, it has caused a paradigm shift from the manufacturing of large-scale to small batches of medicines tailored accordingly to the specific needs of patients. This study aimed to formulate and fabricate two-layered 3D tablets using the digital light processing (DLP) technique. Hydrochlorothiazide (HHT,5%,w/w) and warfarin sodium (WS,5%,w/w) were selected as model drugs. The printing process was initiated with 0.1% of photoinitiator, at a constant ratio of poly(ethylene glycol)diacrylate and poly(ethylene glycol) 400, 1:1, with the addition of water (10%,w/w). Single-layered tablets of 8.00 mm diameter and 1.50 mm thickness, containing HHT and WS respectively, were successfully printed, as well as combined two-layered 3D tablets, with each of the active substances in separate layers. Dissolution tests of single-layered tablets showed immediate, but incomplete release of WS (81.47±1.47%, after 45min), and prolonged and complete release of HHT (98.17±3.11%, after 8h), while significantly slower and incomplete release of both drugs from the combined two-layered 3D tablets was observed. The absence of drug-polymer interaction and presence of a layered cross-sectional tablet structure were confirmed. DLP technique enables simple and rapid fabrication of combined two-layered 3D tablets, while further optimization of formulation factors is necessary to achieve complete drug release. |
| first_indexed | 2024-04-10T19:04:00Z |
| format | Article |
| id | doaj.art-f6c93a78c8fe42c5941f35a0469186ba |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-04-10T19:04:00Z |
| publishDate | 2022-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-f6c93a78c8fe42c5941f35a0469186ba2023-01-31T07:50:28ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672022-01-0172667468810.5937/arhfarm72-403650004-19632206674ADigital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypillAdamov Ivana0Medarević Đorđe1https://orcid.org/0000-0003-4516-2575Ivković Branka2https://orcid.org/0000-0001-7350-3483Ivković Aleksandar3Ibrić Svetlana4https://orcid.org/0000-0003-1101-6174Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju i kozmetologiju, Beograd, SerbiaUniverzitet u Beogradu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju i kozmetologiju, Beograd, SerbiaUniverzitet u Beogradu, Farmaceutski fakultet, Katedra za farmaceutsku hemiju, Beograd, SerbiaAkademija tehničkih strukovnih studija, Beograd, SerbiaUniverzitet u Beogradu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju i kozmetologiju, Beograd, SerbiaEver since 3D printing was introduced to the field of pharmacy, it has caused a paradigm shift from the manufacturing of large-scale to small batches of medicines tailored accordingly to the specific needs of patients. This study aimed to formulate and fabricate two-layered 3D tablets using the digital light processing (DLP) technique. Hydrochlorothiazide (HHT,5%,w/w) and warfarin sodium (WS,5%,w/w) were selected as model drugs. The printing process was initiated with 0.1% of photoinitiator, at a constant ratio of poly(ethylene glycol)diacrylate and poly(ethylene glycol) 400, 1:1, with the addition of water (10%,w/w). Single-layered tablets of 8.00 mm diameter and 1.50 mm thickness, containing HHT and WS respectively, were successfully printed, as well as combined two-layered 3D tablets, with each of the active substances in separate layers. Dissolution tests of single-layered tablets showed immediate, but incomplete release of WS (81.47±1.47%, after 45min), and prolonged and complete release of HHT (98.17±3.11%, after 8h), while significantly slower and incomplete release of both drugs from the combined two-layered 3D tablets was observed. The absence of drug-polymer interaction and presence of a layered cross-sectional tablet structure were confirmed. DLP technique enables simple and rapid fabrication of combined two-layered 3D tablets, while further optimization of formulation factors is necessary to achieve complete drug release.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632206674A.pdfdlp techniquehydrochlorothiazidewarfarin sodiumcombined two-layered 3d tabletspersonalized medicine |
| spellingShingle | Adamov Ivana Medarević Đorđe Ivković Branka Ivković Aleksandar Ibrić Svetlana Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill Arhiv za farmaciju dlp technique hydrochlorothiazide warfarin sodium combined two-layered 3d tablets personalized medicine |
| title | Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill |
| title_full | Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill |
| title_fullStr | Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill |
| title_full_unstemmed | Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill |
| title_short | Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: The concept of a combined polypill |
| title_sort | digital light processing dlp 3d printing technique applied in the fabrication of two layered tablets the concept of a combined polypill |
| topic | dlp technique hydrochlorothiazide warfarin sodium combined two-layered 3d tablets personalized medicine |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2022/0004-19632206674A.pdf |
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