Spindle Checkpoint Regulators in Insulin Signaling
The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes. These critical pathways have been extensively investigat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2018.00161/full |
| _version_ | 1818029348934909952 |
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| author | Eunhee Choi Hongtao Yu |
| author_facet | Eunhee Choi Hongtao Yu |
| author_sort | Eunhee Choi |
| collection | DOAJ |
| description | The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes. These critical pathways have been extensively investigated, but a link between the two has not been established until recently. Our recent study reveals a critical role of spindle checkpoint regulators in insulin signaling and metabolic homeostasis through regulating endocytosis of the insulin receptor (IR). These findings have linked spindle checkpoint proteins to metabolic regulation, expanding the connection between cell division and metabolism. Here, we briefly review the unexpected roles of spindle checkpoint regulators in vesicle trafficking and insulin signaling. |
| first_indexed | 2024-12-10T05:18:16Z |
| format | Article |
| id | doaj.art-f6c9c64b22a04fa497d697e974a2790d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-10T05:18:16Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f6c9c64b22a04fa497d697e974a2790d2022-12-22T02:00:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2018-11-01610.3389/fcell.2018.00161431235Spindle Checkpoint Regulators in Insulin SignalingEunhee ChoiHongtao YuThe spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes. These critical pathways have been extensively investigated, but a link between the two has not been established until recently. Our recent study reveals a critical role of spindle checkpoint regulators in insulin signaling and metabolic homeostasis through regulating endocytosis of the insulin receptor (IR). These findings have linked spindle checkpoint proteins to metabolic regulation, expanding the connection between cell division and metabolism. Here, we briefly review the unexpected roles of spindle checkpoint regulators in vesicle trafficking and insulin signaling.https://www.frontiersin.org/article/10.3389/fcell.2018.00161/fullspindle checkpointmitosisinsulin signalingendocytosisinsulin receptorevolutionary repurposing |
| spellingShingle | Eunhee Choi Hongtao Yu Spindle Checkpoint Regulators in Insulin Signaling Frontiers in Cell and Developmental Biology spindle checkpoint mitosis insulin signaling endocytosis insulin receptor evolutionary repurposing |
| title | Spindle Checkpoint Regulators in Insulin Signaling |
| title_full | Spindle Checkpoint Regulators in Insulin Signaling |
| title_fullStr | Spindle Checkpoint Regulators in Insulin Signaling |
| title_full_unstemmed | Spindle Checkpoint Regulators in Insulin Signaling |
| title_short | Spindle Checkpoint Regulators in Insulin Signaling |
| title_sort | spindle checkpoint regulators in insulin signaling |
| topic | spindle checkpoint mitosis insulin signaling endocytosis insulin receptor evolutionary repurposing |
| url | https://www.frontiersin.org/article/10.3389/fcell.2018.00161/full |
| work_keys_str_mv | AT eunheechoi spindlecheckpointregulatorsininsulinsignaling AT hongtaoyu spindlecheckpointregulatorsininsulinsignaling |