Interaction of Adenosine, Modified Using Carborane Clusters, with Ovarian Cancer Cells: A New Anticancer Approach against Chemoresistance

Interaction of Adenosine, Modified Using Carborane Clusters, with Ovarian Cancer Cells: A New Anticancer Approach against Chemoresistance

Platinum compounds remain the first-line drugs for the treatment of most lethal gynecological malignancies and ovarian cancers. Acquired platinum resistance remains a major challenge in gynecological oncology. Considering the unique physicochemical properties of the metallacarboranes modifier and th...

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Bibliographic Details
Main Authors: Katarzyna Bednarska-Szczepaniak, Ewelina Przelazły, Katarzyna Dominika Kania, Marzena Szwed, Miroslava Litecká, Bohumír Grűner, Zbigniew J. Leśnikowski
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
ovarian cancer
chemoresistance
cancer spheroids
cisplatin
apoptosis
reactive oxygen species
Online Access:https://www.mdpi.com/2072-6694/13/15/3855

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