Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hema...

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Bibliographic Details
Main Authors: Hao Wang, Gurbakhash Kaur, Alexander I. Sankin, Fuxiang Chen, Fangxia Guan, Xingxing Zang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Hematology & Oncology
Subjects:
Hematologic malignancies
Immune checkpoints
CAR-T
Immunotherapy
CTLA-4
PD-1
Online Access:http://link.springer.com/article/10.1186/s13045-019-0746-1

Internet

http://link.springer.com/article/10.1186/s13045-019-0746-1

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