Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling

Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling

Purpose: Drug resistance has been recognized to be a major obstacle to the chemotherapy for osteosarcoma. And the potential importance of hypoxia as a target to reverse drug resistance in osteosarcoma has been indicated, though the mechanism underlining such role is not clarified. The present study...

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Bibliographic Details
Main Authors:	Changfu Zhao, Qiao Zhang, Tao Yu, Shudong Sun, Wenjun Wang, Guangyao Liu
Format:	Article
Language:	English
Published:	Elsevier 2016-03-01
Series:	Journal of Bone Oncology
Subjects:	Hypoxia Osteosarcoma cells Doxorubicin Resistance AMPK signaling
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212137415300816

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