Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review
(1) Introduction: Restriction in sodium intake is an important strategy for reducing cardiovascular morbidity and mortality, considering the direct influence of high-sodium diet consumption on the development of hypertension and cardiovascular diseases. There are only a few studies dealing with the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/599 |
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| author | Guilherme da Silva Ferreira Sergio Catanozi Marisa Passarelli |
| author_facet | Guilherme da Silva Ferreira Sergio Catanozi Marisa Passarelli |
| author_sort | Guilherme da Silva Ferreira |
| collection | DOAJ |
| description | (1) Introduction: Restriction in sodium intake is an important strategy for reducing cardiovascular morbidity and mortality, considering the direct influence of high-sodium diet consumption on the development of hypertension and cardiovascular diseases. There are only a few studies dealing with the influence of dietary sodium on the development of nonalcoholic fatty liver disease (NAFLD). In this systematic review, evidence in humans and animal models was compiled in a critical view of the influence of dietary sodium intake patterns on NAFLD markers; (2) Methods: Systematic review of PubMed data. Clinical outcomes included the prevalence/incidence of NAFLD for human studies, and NAFLD markers (hepatic lipogenesis, and markers of steatosis, fibrosis, and inflammation) for animal studies. The protocol was registered at the International Prospective Register of Systematic Review (PROSPERO; CRD42023390447); (3) Results and Conclusion: Seven studies in humans and eight in animals were included. All studies in humans were observational and associated high-sodium intake with NAFLD. However, in animals, both the increased and reduced consumption of sodium negatively influenced markers of liver steatosis, inflammation, and fibrosis. |
| first_indexed | 2024-03-11T07:01:05Z |
| format | Article |
| id | doaj.art-f6ce71d638004e6d8662c85591d57972 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:01:05Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f6ce71d638004e6d8662c85591d579722023-11-17T09:17:04ZengMDPI AGAntioxidants2076-39212023-02-0112359910.3390/antiox12030599Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic ReviewGuilherme da Silva Ferreira0Sergio Catanozi1Marisa Passarelli2Laboratorio de Lipides (LIM-10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 01246-000, BrazilLaboratorio de Lipides (LIM-10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 01246-000, BrazilLaboratorio de Lipides (LIM-10), Hospital das Clinicas (HCFMUSP) da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo 01246-000, Brazil(1) Introduction: Restriction in sodium intake is an important strategy for reducing cardiovascular morbidity and mortality, considering the direct influence of high-sodium diet consumption on the development of hypertension and cardiovascular diseases. There are only a few studies dealing with the influence of dietary sodium on the development of nonalcoholic fatty liver disease (NAFLD). In this systematic review, evidence in humans and animal models was compiled in a critical view of the influence of dietary sodium intake patterns on NAFLD markers; (2) Methods: Systematic review of PubMed data. Clinical outcomes included the prevalence/incidence of NAFLD for human studies, and NAFLD markers (hepatic lipogenesis, and markers of steatosis, fibrosis, and inflammation) for animal studies. The protocol was registered at the International Prospective Register of Systematic Review (PROSPERO; CRD42023390447); (3) Results and Conclusion: Seven studies in humans and eight in animals were included. All studies in humans were observational and associated high-sodium intake with NAFLD. However, in animals, both the increased and reduced consumption of sodium negatively influenced markers of liver steatosis, inflammation, and fibrosis.https://www.mdpi.com/2076-3921/12/3/599sodium consumptiondietary sodiumnonalcoholic fatty liver diseasesteatosis |
| spellingShingle | Guilherme da Silva Ferreira Sergio Catanozi Marisa Passarelli Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review Antioxidants sodium consumption dietary sodium nonalcoholic fatty liver disease steatosis |
| title | Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_full | Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_fullStr | Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_full_unstemmed | Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_short | Dietary Sodium and Nonalcoholic Fatty Liver Disease: A Systematic Review |
| title_sort | dietary sodium and nonalcoholic fatty liver disease a systematic review |
| topic | sodium consumption dietary sodium nonalcoholic fatty liver disease steatosis |
| url | https://www.mdpi.com/2076-3921/12/3/599 |
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