An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression
Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown. Here the authors identify composite DNA elements (NCCEs) that bind NKX2 homeodomain proteins cooperatively with COUP-TFII to define a morphogenetic cod...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34991-2 |
| _version_ | 1811207711766872064 |
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| author | Thanh Theresa Dinh Menglan Xiang Anusha Rajaraman Yongzhi Wang Nicole Salazar Yu Zhu Walter Roper Siyeon Rhee Kevin Brulois Ed O’Hara Helena Kiefel Truc M. Dinh Yuhan Bi Dalila Gonzalez Evan P. Bao Kristy Red-Horse Peter Balogh Fanni Gábris Balázs Gaszner Gergely Berta Junliang Pan Eugene C. Butcher |
| author_facet | Thanh Theresa Dinh Menglan Xiang Anusha Rajaraman Yongzhi Wang Nicole Salazar Yu Zhu Walter Roper Siyeon Rhee Kevin Brulois Ed O’Hara Helena Kiefel Truc M. Dinh Yuhan Bi Dalila Gonzalez Evan P. Bao Kristy Red-Horse Peter Balogh Fanni Gábris Balázs Gaszner Gergely Berta Junliang Pan Eugene C. Butcher |
| author_sort | Thanh Theresa Dinh |
| collection | DOAJ |
| description | Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown. Here the authors identify composite DNA elements (NCCEs) that bind NKX2 homeodomain proteins cooperatively with COUP-TFII to define a morphogenetic code that targets transcription of mucosal vascular addressins. |
| first_indexed | 2024-04-12T04:08:08Z |
| format | Article |
| id | doaj.art-f6ce820708cb43eaa9ef6fbfae5e3a7a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T04:08:08Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f6ce820708cb43eaa9ef6fbfae5e3a7a2022-12-22T03:48:34ZengNature PortfolioNature Communications2041-17232022-12-0113111410.1038/s41467-022-34991-2An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expressionThanh Theresa Dinh0Menglan Xiang1Anusha Rajaraman2Yongzhi Wang3Nicole Salazar4Yu Zhu5Walter Roper6Siyeon Rhee7Kevin Brulois8Ed O’Hara9Helena Kiefel10Truc M. Dinh11Yuhan Bi12Dalila Gonzalez13Evan P. Bao14Kristy Red-Horse15Peter Balogh16Fanni Gábris17Balázs Gaszner18Gergely Berta19Junliang Pan20Eugene C. Butcher21Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineColumbia University Vagelos College of Physicians and SurgeonsDepartment of Biology, Stanford UniversityLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicinePalo Alto Veterans Institute for ResearchLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicinePalo Alto Veterans Institute for ResearchLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineUniversity of California, San DiegoPalo Alto Veterans Institute for ResearchDepartment of Biology, Stanford UniversityDepartment of Immunology and Biotechnology, University of Pécs Medical SchoolDepartment of Immunology and Biotechnology, University of Pécs Medical SchoolDepartment of Anatomy, University of Pécs Medical SchoolDepartment of Medical Biology and Central Electron Microscopy Laboratory, University of Pécs Medical SchoolPalo Alto Veterans Institute for ResearchLaboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of MedicineVascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown. Here the authors identify composite DNA elements (NCCEs) that bind NKX2 homeodomain proteins cooperatively with COUP-TFII to define a morphogenetic code that targets transcription of mucosal vascular addressins.https://doi.org/10.1038/s41467-022-34991-2 |
| spellingShingle | Thanh Theresa Dinh Menglan Xiang Anusha Rajaraman Yongzhi Wang Nicole Salazar Yu Zhu Walter Roper Siyeon Rhee Kevin Brulois Ed O’Hara Helena Kiefel Truc M. Dinh Yuhan Bi Dalila Gonzalez Evan P. Bao Kristy Red-Horse Peter Balogh Fanni Gábris Balázs Gaszner Gergely Berta Junliang Pan Eugene C. Butcher An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression Nature Communications |
| title | An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression |
| title_full | An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression |
| title_fullStr | An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression |
| title_full_unstemmed | An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression |
| title_short | An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression |
| title_sort | nkx coup tfii morphogenetic code directs mucosal endothelial addressin expression |
| url | https://doi.org/10.1038/s41467-022-34991-2 |
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