An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression

An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression

Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown. Here the authors identify composite DNA elements (NCCEs) that bind NKX2 homeodomain proteins cooperatively with COUP-TFII to define a morphogenetic cod...

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Bibliographic Details
Main Authors: Thanh Theresa Dinh, Menglan Xiang, Anusha Rajaraman, Yongzhi Wang, Nicole Salazar, Yu Zhu, Walter Roper, Siyeon Rhee, Kevin Brulois, Ed O’Hara, Helena Kiefel, Truc M. Dinh, Yuhan Bi, Dalila Gonzalez, Evan P. Bao, Kristy Red-Horse, Peter Balogh, Fanni Gábris, Balázs Gaszner, Gergely Berta, Junliang Pan, Eugene C. Butcher
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34991-2

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