The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza
AIM. To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. MATERIALS AND METHODS. The investigators examined 1203 patients (387 children, 509 peo...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2014-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31581 |
| _version_ | 1818961937932746752 |
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| author | L V Kolobukhina E I Burtseva M Iu Shchelkanov S V Al'khovskiĭ A G Prilipov L N Merkulova L B Kisteneva R V Vartanian I S Kruzhkova S V Trushakova K G Krasnoslobovtsev S N Avdeev O A Sutochnikova M V Bazarova E I Kelli O E Ambrosi N A Malyshev D K L'vov A G Chuchalin |
| author_facet | L V Kolobukhina E I Burtseva M Iu Shchelkanov S V Al'khovskiĭ A G Prilipov L N Merkulova L B Kisteneva R V Vartanian I S Kruzhkova S V Trushakova K G Krasnoslobovtsev S N Avdeev O A Sutochnikova M V Bazarova E I Kelli O E Ambrosi N A Malyshev D K L'vov A G Chuchalin |
| author_sort | L V Kolobukhina |
| collection | DOAJ |
| description | AIM. To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. MATERIALS AND METHODS. The investigators examined 1203 patients (387 children, 509 people older than 16 years of age, 307 pregnant women) admitted to Moscow Clinical Infectious Diseases Hospital One with the clinical signs of acute respiratory viral diseases. Nasal lavage and autopsy specimens were used to isolate viral strains, then to sequence genomic fragments, and to determine receptor specificity. RESULTS. Out of the 1203 examinees, 284 (23.6%) were influenza-positive: 221 (77.8%), 24 (8.5%), and 39 (13.7%) patients had influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B, respectively. Influenza was notified in 42,7% of the pregnant women. There was a preponderance of its moderate form; its severe form developed in single cases having comorbidities. One fatal outcome was registered. The intake of antiviral medications in the first 48 hours of the disease could prevent complications. The investigators revealed mutations in the strain isolated from the bronchoalveolar lavage fluid of a patient with severe pneumonia complicated by acute respiratory distress syndrome. CONCLUSION. There is evidence that there are mutant A(H1N1)pdm09 viruses that have high pneumotropicity. The high risk of their circulation in the population and the risk of severe influenza forms involving the lower respiratory tract remain. Early antiviral therapy in the first 36-48 hours diminishes the clinical manifestations of influenza and reduces the risk of developing complications. |
| first_indexed | 2024-12-20T12:21:22Z |
| format | Article |
| id | doaj.art-f6d06c11c9b3464ba8eb45827e1d5fbf |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T12:21:22Z |
| publishDate | 2014-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-f6d06c11c9b3464ba8eb45827e1d5fbf2022-12-21T19:40:59Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422014-10-018610525928598The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenzaL V KolobukhinaE I BurtsevaM Iu ShchelkanovS V Al'khovskiĭA G PrilipovL N MerkulovaL B KistenevaR V VartanianI S KruzhkovaS V TrushakovaK G KrasnoslobovtsevS N AvdeevO A SutochnikovaM V BazarovaE I KelliO E AmbrosiN A MalyshevD K L'vovA G ChuchalinAIM. To characterize the 2013-2014 epidemic season from the results of detection of influenza infection in patients; to provide the molecular genetic characteristics of the strains isolated from deceased patients. MATERIALS AND METHODS. The investigators examined 1203 patients (387 children, 509 people older than 16 years of age, 307 pregnant women) admitted to Moscow Clinical Infectious Diseases Hospital One with the clinical signs of acute respiratory viral diseases. Nasal lavage and autopsy specimens were used to isolate viral strains, then to sequence genomic fragments, and to determine receptor specificity. RESULTS. Out of the 1203 examinees, 284 (23.6%) were influenza-positive: 221 (77.8%), 24 (8.5%), and 39 (13.7%) patients had influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B, respectively. Influenza was notified in 42,7% of the pregnant women. There was a preponderance of its moderate form; its severe form developed in single cases having comorbidities. One fatal outcome was registered. The intake of antiviral medications in the first 48 hours of the disease could prevent complications. The investigators revealed mutations in the strain isolated from the bronchoalveolar lavage fluid of a patient with severe pneumonia complicated by acute respiratory distress syndrome. CONCLUSION. There is evidence that there are mutant A(H1N1)pdm09 viruses that have high pneumotropicity. The high risk of their circulation in the population and the risk of severe influenza forms involving the lower respiratory tract remain. Early antiviral therapy in the first 36-48 hours diminishes the clinical manifestations of influenza and reduces the risk of developing complications.https://ter-arkhiv.ru/0040-3660/article/view/31581influenza2013-2014 epidemic seasoninfluenza a(h3n2) and a(h1n1)pdm09 virusesinfluenza b virusmolecular genetic propertiesantiviral medicationsingavirin |
| spellingShingle | L V Kolobukhina E I Burtseva M Iu Shchelkanov S V Al'khovskiĭ A G Prilipov L N Merkulova L B Kisteneva R V Vartanian I S Kruzhkova S V Trushakova K G Krasnoslobovtsev S N Avdeev O A Sutochnikova M V Bazarova E I Kelli O E Ambrosi N A Malyshev D K L'vov A G Chuchalin The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza Терапевтический архив influenza 2013-2014 epidemic season influenza a(h3n2) and a(h1n1)pdm09 viruses influenza b virus molecular genetic properties antiviral medications ingavirin |
| title | The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza |
| title_full | The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza |
| title_fullStr | The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza |
| title_full_unstemmed | The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza |
| title_short | The 2013-2014 epidemic season. Hospital monitoring and antiviral therapy for influenza |
| title_sort | 2013 2014 epidemic season hospital monitoring and antiviral therapy for influenza |
| topic | influenza 2013-2014 epidemic season influenza a(h3n2) and a(h1n1)pdm09 viruses influenza b virus molecular genetic properties antiviral medications ingavirin |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31581 |
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