Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices
Additive manufacturing (AM) is a versatile technology with potential applications in healthcare and medical instruments, where surface disinfection or sterilization is essential. This study comprehensively the effect of commonly used cost-effective disinfectants, ethanol (70 V/V%) and chlorine solut...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523010328 |
| _version_ | 1827375641720258560 |
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| author | Kinga Kardos Roland Told Attila Pentek Nitin Sahai Krisztina Banfai Andras Vizi Arnold Koltai Peter Szabo Zsuzsanna Gurdan Judit Bovari-Biri Judit E. Pongracz Elek Telek Andras Lukacs Peter Maroti |
| author_facet | Kinga Kardos Roland Told Attila Pentek Nitin Sahai Krisztina Banfai Andras Vizi Arnold Koltai Peter Szabo Zsuzsanna Gurdan Judit Bovari-Biri Judit E. Pongracz Elek Telek Andras Lukacs Peter Maroti |
| author_sort | Kinga Kardos |
| collection | DOAJ |
| description | Additive manufacturing (AM) is a versatile technology with potential applications in healthcare and medical instruments, where surface disinfection or sterilization is essential. This study comprehensively the effect of commonly used cost-effective disinfectants, ethanol (70 V/V%) and chlorine solution on the mechanical and thermal properties of flexible 3D printed materials. The following materials were tested before and after a 5-cycle surface disinfection: Flexfill TPE 90A, Phyton Flex (TPU) for material extrusion, Flexible (resin), Elastic 50A (resin) for vat photopolymerization and Flexa Black (TPU) material for powder bed fusion technology. Mechanical tests included tensile, compression, Charpy impact, flex resistance and stress relaxation tests, as well as Shore A hardness and volume measurements. The structure was analyzed using scanning electron microscopy (SEM)and Raman spectroscopy. The cytotoxicity was assessed using a A549 cell viability assay. The results show that after disinfection, significant changes occurred mainly in the tensile and Shore A properties, such as the tensile strength of the disinfected Flexible (resin) materials was 3.44 MPa ± 0.51 MPa (ethanol) and 2.62 MPa ± 0.31 MPa compared to the native 2.02 MPa ± 0.24 MPa. Interestingly, the applied surface disinfectants can negatively affect biocompatibility. Medical devices have been designed and fabricated based on the findings. Our findings can serve as a guide to the potential applications of commonly used 3D printed flexible materials in the biomedical field. |
| first_indexed | 2024-03-08T11:54:58Z |
| format | Article |
| id | doaj.art-f6d08d1bad0048fab326b96c59139661 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-08T11:54:58Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-f6d08d1bad0048fab326b96c591396612024-01-24T05:16:46ZengElsevierMaterials & Design0264-12752024-01-01237112616Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devicesKinga Kardos0Roland Told1Attila Pentek2Nitin Sahai3Krisztina Banfai4Andras Vizi5Arnold Koltai6Peter Szabo7Zsuzsanna Gurdan8Judit Bovari-Biri9Judit E. Pongracz10Elek Telek11Andras Lukacs12Peter Maroti133D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary3D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary3D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary3D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary; Department of Biomedical Engineering, North Eastern Hill University, Shillong 793022, Meghalaya, IndiaDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, H-7624, Pecs, Rokus Str. 2, HungaryDepartment of Biophysics, University of Pecs, Medical School, H-7624, Pecs, Szigeti Str. 12, HungaryMedical Skills Education and Innovation Centre, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, HungaryInstitute of Geography and Earth Sciences, University of Pecs, Faculty of Sciences, H-7624 Pécs, Ifjusag Str. 6, HungaryDepartment of Paediatric and Adolescent Dentistry, Medical School, University of Pecs, Tüzér Str. 1., H-7624 Pécs, HungaryDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, H-7624, Pecs, Rokus Str. 2, HungaryDepartment of Pharmaceutical Biotechnology, Faculty of Pharmacy, University of Pecs, H-7624, Pecs, Rokus Str. 2, HungaryDepartment of Biophysics, University of Pecs, Medical School, H-7624, Pecs, Szigeti Str. 12, HungaryDepartment of Biophysics, University of Pecs, Medical School, H-7624, Pecs, Szigeti Str. 12, Hungary3D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary; Medical Skills Education and Innovation Centre, Medical School, University of Pecs, Szigeti Str. 12, H-7624 Pecs, Hungary; Corresponding author at: 3D Printing and Visualization Center, University of Pecs, H-7624, Pecs, Boszorkany Str. 2, Hungary.Additive manufacturing (AM) is a versatile technology with potential applications in healthcare and medical instruments, where surface disinfection or sterilization is essential. This study comprehensively the effect of commonly used cost-effective disinfectants, ethanol (70 V/V%) and chlorine solution on the mechanical and thermal properties of flexible 3D printed materials. The following materials were tested before and after a 5-cycle surface disinfection: Flexfill TPE 90A, Phyton Flex (TPU) for material extrusion, Flexible (resin), Elastic 50A (resin) for vat photopolymerization and Flexa Black (TPU) material for powder bed fusion technology. Mechanical tests included tensile, compression, Charpy impact, flex resistance and stress relaxation tests, as well as Shore A hardness and volume measurements. The structure was analyzed using scanning electron microscopy (SEM)and Raman spectroscopy. The cytotoxicity was assessed using a A549 cell viability assay. The results show that after disinfection, significant changes occurred mainly in the tensile and Shore A properties, such as the tensile strength of the disinfected Flexible (resin) materials was 3.44 MPa ± 0.51 MPa (ethanol) and 2.62 MPa ± 0.31 MPa compared to the native 2.02 MPa ± 0.24 MPa. Interestingly, the applied surface disinfectants can negatively affect biocompatibility. Medical devices have been designed and fabricated based on the findings. Our findings can serve as a guide to the potential applications of commonly used 3D printed flexible materials in the biomedical field.http://www.sciencedirect.com/science/article/pii/S0264127523010328DisinfectionMechanical testCytotoxicityFlexible MaterialAdditive manufacturingMedical device |
| spellingShingle | Kinga Kardos Roland Told Attila Pentek Nitin Sahai Krisztina Banfai Andras Vizi Arnold Koltai Peter Szabo Zsuzsanna Gurdan Judit Bovari-Biri Judit E. Pongracz Elek Telek Andras Lukacs Peter Maroti Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices Materials & Design Disinfection Mechanical test Cytotoxicity Flexible Material Additive manufacturing Medical device |
| title | Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| title_full | Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| title_fullStr | Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| title_full_unstemmed | Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| title_short | Surface disinfection change the mechanical, structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| title_sort | surface disinfection change the mechanical structural and biological properties of flexible materials used for additive manufacturing of medical devices |
| topic | Disinfection Mechanical test Cytotoxicity Flexible Material Additive manufacturing Medical device |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523010328 |
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