PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system

PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system

Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering lipid metabolism, PCSK9 also influences vascular...

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Bibliographic Details
Main Authors: Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Format: Article
Language:English
Published: AIP Publishing LLC 2023-12-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0167440

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