Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs)
Background and purpose: Gastrointestinal stromal tumors (GISTs) are rare diseases of the gastrointestinal tract but they are the most common gastrointestinal tumors of mesenchymal origin. Since most GISTs have malignant potential, their probability of malignant progression must be evaluated. This st...
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2763 |
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| author | Jin Hwa Park Bo-kyeong Kang Hang Lak Lee Jai Hoon Yoon Kang Nyeong Lee Dae Won Jun Oh Young Lee Dong Soo Han Byung Chul Yoon Ho Soon Choi |
| author_facet | Jin Hwa Park Bo-kyeong Kang Hang Lak Lee Jai Hoon Yoon Kang Nyeong Lee Dae Won Jun Oh Young Lee Dong Soo Han Byung Chul Yoon Ho Soon Choi |
| author_sort | Jin Hwa Park |
| collection | DOAJ |
| description | Background and purpose: Gastrointestinal stromal tumors (GISTs) are rare diseases of the gastrointestinal tract but they are the most common gastrointestinal tumors of mesenchymal origin. Since most GISTs have malignant potential, their probability of malignant progression must be evaluated. This study was conducted to examine the correlation between three-dimensional GIST volume measured by CT and malignant potential. Materials and methods: A retrospective study was performed on 70 patients diagnosed with GIST after surgical resection in Hanyang University Seoul Hospital from 2012 to 2017. Linear regression analysis was used to establish which between the length of the long axis of GISTs, originally considered a predictor of malignancy, and their volume was a more accurate predictor of malignancy. Tumor dimensions were measured by CT. Results: Data were analyzed using the chi-square test or Student’s <i>t</i>-test and logistic regression. Of the GISTs, 53 (75.71%) were in the stomach, 3 (4.29%) in the small intestine, and 14 (20.0%) in the large intestine. The mean age of the malignant GIST group was significantly higher than that of the benign GIST group (<i>p</i> = 0.032), their tumor long axes were significantly greater (<i>p</i> = 0.073), their tumor volumes were significantly larger (<i>p</i> = 0.001), and the frequency of tumor necrosis was higher (<i>p</i> = 0.001). In multivariate analysis, malignant GIST was associated with location in organs other than the stomach (OR 7.846, 95% CI 1.293–47.624, <i>p</i> = 0.025), longer axis (OR 1.037, 95% CI 1.011–1.065, <i>p</i> = 0.006), larger volume (OR 1.003, 95% CI 1.000–1.006, <i>p</i> = 0.029), and necrosis (OR 12.222, 95% CI 1.945–76.794, <i>p</i> = 0.008). The mean age of the recurrent GIST group was higher than that of the non-recurrent group (<i>p</i> = 0.045), their tumor long axes were significantly longer (<i>p</i> = 0.005), and their volumes were greater, but this last difference was not significant (<i>p</i> = 0.072). Conclusions: Tumor volume can be considered an additional risk factor in assessing the malignant potential of GISTs and tends to increase in recurrent GISTs. |
| first_indexed | 2024-03-10T16:48:22Z |
| format | Article |
| id | doaj.art-f6d0d0fa28ff4d23ba22737a1e6fa3c2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:48:22Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f6d0d0fa28ff4d23ba22737a1e6fa3c22023-11-20T11:26:00ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0199276310.3390/jcm9092763Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs)Jin Hwa Park0Bo-kyeong Kang1Hang Lak Lee2Jai Hoon Yoon3Kang Nyeong Lee4Dae Won Jun5Oh Young Lee6Dong Soo Han7Byung Chul Yoon8Ho Soon Choi9Department of Internal Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Radiology, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Guri 11923, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaDepartment of Internal Medicine, Hanyang University School of Medicine, Seoul 04763, KoreaBackground and purpose: Gastrointestinal stromal tumors (GISTs) are rare diseases of the gastrointestinal tract but they are the most common gastrointestinal tumors of mesenchymal origin. Since most GISTs have malignant potential, their probability of malignant progression must be evaluated. This study was conducted to examine the correlation between three-dimensional GIST volume measured by CT and malignant potential. Materials and methods: A retrospective study was performed on 70 patients diagnosed with GIST after surgical resection in Hanyang University Seoul Hospital from 2012 to 2017. Linear regression analysis was used to establish which between the length of the long axis of GISTs, originally considered a predictor of malignancy, and their volume was a more accurate predictor of malignancy. Tumor dimensions were measured by CT. Results: Data were analyzed using the chi-square test or Student’s <i>t</i>-test and logistic regression. Of the GISTs, 53 (75.71%) were in the stomach, 3 (4.29%) in the small intestine, and 14 (20.0%) in the large intestine. The mean age of the malignant GIST group was significantly higher than that of the benign GIST group (<i>p</i> = 0.032), their tumor long axes were significantly greater (<i>p</i> = 0.073), their tumor volumes were significantly larger (<i>p</i> = 0.001), and the frequency of tumor necrosis was higher (<i>p</i> = 0.001). In multivariate analysis, malignant GIST was associated with location in organs other than the stomach (OR 7.846, 95% CI 1.293–47.624, <i>p</i> = 0.025), longer axis (OR 1.037, 95% CI 1.011–1.065, <i>p</i> = 0.006), larger volume (OR 1.003, 95% CI 1.000–1.006, <i>p</i> = 0.029), and necrosis (OR 12.222, 95% CI 1.945–76.794, <i>p</i> = 0.008). The mean age of the recurrent GIST group was higher than that of the non-recurrent group (<i>p</i> = 0.045), their tumor long axes were significantly longer (<i>p</i> = 0.005), and their volumes were greater, but this last difference was not significant (<i>p</i> = 0.072). Conclusions: Tumor volume can be considered an additional risk factor in assessing the malignant potential of GISTs and tends to increase in recurrent GISTs.https://www.mdpi.com/2077-0383/9/9/2763GIST (gastrointestinal stromal tumors)malignancyvolumesize |
| spellingShingle | Jin Hwa Park Bo-kyeong Kang Hang Lak Lee Jai Hoon Yoon Kang Nyeong Lee Dae Won Jun Oh Young Lee Dong Soo Han Byung Chul Yoon Ho Soon Choi Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) Journal of Clinical Medicine GIST (gastrointestinal stromal tumors) malignancy volume size |
| title | Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) |
| title_full | Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) |
| title_fullStr | Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) |
| title_full_unstemmed | Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) |
| title_short | Correlation between Three-Dimensional Volume and Malignant Potential of Gastrointestinal Stromal Tumors (GISTs) |
| title_sort | correlation between three dimensional volume and malignant potential of gastrointestinal stromal tumors gists |
| topic | GIST (gastrointestinal stromal tumors) malignancy volume size |
| url | https://www.mdpi.com/2077-0383/9/9/2763 |
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