Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection
In 1940, van Wagenen and Herren first proposed the corpus callosotomy (CC) as a surgical procedure for epilepsy. CC has been mainly used to treat drop attacks, which are classified as generalized tonic or atonic seizures. Epileptic spasms (ESs) are a type of epileptic seizure characterized as brief...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/12/1601 |
| _version_ | 1797506484361232384 |
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| author | Tohru Okanishi Ayataka Fujimoto |
| author_facet | Tohru Okanishi Ayataka Fujimoto |
| author_sort | Tohru Okanishi |
| collection | DOAJ |
| description | In 1940, van Wagenen and Herren first proposed the corpus callosotomy (CC) as a surgical procedure for epilepsy. CC has been mainly used to treat drop attacks, which are classified as generalized tonic or atonic seizures. Epileptic spasms (ESs) are a type of epileptic seizure characterized as brief muscle contractions with ictal polyphasic slow waves on an electroencephalogram and a main feature of West syndrome. Resection surgeries, including frontal/posterior disconnections and hemispherotomy, have been established for the treatment of medically intractable ES in patients with unilaterally localized epileptogenic regions. However, CC has also been adopted for ES treatment, with studies involving CC to treat ES having increased since 2010. In those studies, patients without lesions observed on magnetic resonance imaging or equally bilateral lesions predominated, in contrast to studies on resection surgeries. Here, we present a review of relevant literature concerning CC and relevant adaptations. We discuss history and adaptations of CC, and patient selection for epilepsy surgeries due to medically intractable ES, and compared resection surgeries with CC. We propose a surgical selection flow involving resection surgery or CC as first-line treatment for patients with ES who have been assessed as suitable candidates for surgery. |
| first_indexed | 2024-03-10T04:33:18Z |
| format | Article |
| id | doaj.art-f6d2910066ac43db89520f527327bcc8 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T04:33:18Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f6d2910066ac43db89520f527327bcc82023-11-23T04:01:54ZengMDPI AGBrain Sciences2076-34252021-12-011112160110.3390/brainsci11121601Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical SelectionTohru Okanishi0Ayataka Fujimoto1Division of Child Neurology, Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago 683-8503, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, JapanIn 1940, van Wagenen and Herren first proposed the corpus callosotomy (CC) as a surgical procedure for epilepsy. CC has been mainly used to treat drop attacks, which are classified as generalized tonic or atonic seizures. Epileptic spasms (ESs) are a type of epileptic seizure characterized as brief muscle contractions with ictal polyphasic slow waves on an electroencephalogram and a main feature of West syndrome. Resection surgeries, including frontal/posterior disconnections and hemispherotomy, have been established for the treatment of medically intractable ES in patients with unilaterally localized epileptogenic regions. However, CC has also been adopted for ES treatment, with studies involving CC to treat ES having increased since 2010. In those studies, patients without lesions observed on magnetic resonance imaging or equally bilateral lesions predominated, in contrast to studies on resection surgeries. Here, we present a review of relevant literature concerning CC and relevant adaptations. We discuss history and adaptations of CC, and patient selection for epilepsy surgeries due to medically intractable ES, and compared resection surgeries with CC. We propose a surgical selection flow involving resection surgery or CC as first-line treatment for patients with ES who have been assessed as suitable candidates for surgery.https://www.mdpi.com/2076-3425/11/12/1601corpus callosotomyepilepsy surgeryepileptic spasmsWest syndromeadaptationsurgical selection |
| spellingShingle | Tohru Okanishi Ayataka Fujimoto Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection Brain Sciences corpus callosotomy epilepsy surgery epileptic spasms West syndrome adaptation surgical selection |
| title | Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection |
| title_full | Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection |
| title_fullStr | Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection |
| title_full_unstemmed | Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection |
| title_short | Corpus Callosotomy for Controlling Epileptic Spasms: A Proposal for Surgical Selection |
| title_sort | corpus callosotomy for controlling epileptic spasms a proposal for surgical selection |
| topic | corpus callosotomy epilepsy surgery epileptic spasms West syndrome adaptation surgical selection |
| url | https://www.mdpi.com/2076-3425/11/12/1601 |
| work_keys_str_mv | AT tohruokanishi corpuscallosotomyforcontrollingepilepticspasmsaproposalforsurgicalselection AT ayatakafujimoto corpuscallosotomyforcontrollingepilepticspasmsaproposalforsurgicalselection |