Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models
Context: The plant Omphalocarpum procerum is used traditionally in Africa to manage female reproductive health issues such as infertility and menstrual cycle regulation. In the search for new therapies for the management of female reproductive issues, the plant O. procerum was investigated in this s...
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| Format: | Article |
| Language: | English |
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GarVal Editorial Ltda.
2020-03-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol8/jppres19.728_8.2.92.pdf |
| _version_ | 1819049244848291840 |
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| author | Enitome Bafor Tosan Eyegbagharen Ejiro Ochoyama MacDonald Idu |
| author_facet | Enitome Bafor Tosan Eyegbagharen Ejiro Ochoyama MacDonald Idu |
| author_sort | Enitome Bafor |
| collection | DOAJ |
| description | Context: The plant Omphalocarpum procerum is used traditionally in Africa to manage female reproductive health issues such as infertility and menstrual cycle regulation. In the search for new therapies for the management of female reproductive issues, the plant O. procerum was investigated in this study.
Aims: To determine the activity of the methanol extract of O. procerum stem bark (MOPS) on uterine contractility, as a measure to determine its usefulness in uterine contractility associated disorders.
Methods: MOPS’ activity on spontaneous, oxytocin, KCl-induced contractions and in calcium-free solution was determined on the isolated uterus. Possible mechanisms of activity were determined using receptor and channel blockers.
Results: MOPS inhibited spontaneous and oxytocin-induced contractions. MOPS also inhibited oxytocin-induced contractions in calcium-free solution. MOPS was also found to exert its inhibitory effect through interaction with β-adrenoceptors in the uterus.
Conclusions: MOPS has been shown to inhibit uterine contractility in the non-pregnant and pregnant uterus primarily through the activation of β-adrenoceptors in the uterus. |
| first_indexed | 2024-12-21T11:29:05Z |
| format | Article |
| id | doaj.art-f6d51284fdb0489c9868da8dbc16bd0e |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-21T11:29:05Z |
| publishDate | 2020-03-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-f6d51284fdb0489c9868da8dbc16bd0e2022-12-21T19:05:36ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502020-03-018292104Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse modelsEnitome Bafor0Tosan Eyegbagharen1Ejiro Ochoyama2MacDonald Idu3Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.Department of Plant Biology and Biotechnology, Faculty of Science, University of Benin, Benin City, Nigeria.Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.Department of Plant Biology and Biotechnology, Faculty of Science, University of Benin, Benin City, Nigeria.Context: The plant Omphalocarpum procerum is used traditionally in Africa to manage female reproductive health issues such as infertility and menstrual cycle regulation. In the search for new therapies for the management of female reproductive issues, the plant O. procerum was investigated in this study. Aims: To determine the activity of the methanol extract of O. procerum stem bark (MOPS) on uterine contractility, as a measure to determine its usefulness in uterine contractility associated disorders. Methods: MOPS’ activity on spontaneous, oxytocin, KCl-induced contractions and in calcium-free solution was determined on the isolated uterus. Possible mechanisms of activity were determined using receptor and channel blockers. Results: MOPS inhibited spontaneous and oxytocin-induced contractions. MOPS also inhibited oxytocin-induced contractions in calcium-free solution. MOPS was also found to exert its inhibitory effect through interaction with β-adrenoceptors in the uterus. Conclusions: MOPS has been shown to inhibit uterine contractility in the non-pregnant and pregnant uterus primarily through the activation of β-adrenoceptors in the uterus.http://jppres.com/jppres/pdf/vol8/jppres19.728_8.2.92.pdflaboroxytocinplant extractpropranololuterus |
| spellingShingle | Enitome Bafor Tosan Eyegbagharen Ejiro Ochoyama MacDonald Idu Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models Journal of Pharmacy & Pharmacognosy Research labor oxytocin plant extract propranolol uterus |
| title | Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models |
| title_full | Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models |
| title_fullStr | Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models |
| title_full_unstemmed | Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models |
| title_short | Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models |
| title_sort | ex vivo inhibition of uterine contractility by the stem bark extracts of omphalocarpum procerum p beauv sapotaceae in mouse models |
| topic | labor oxytocin plant extract propranolol uterus |
| url | http://jppres.com/jppres/pdf/vol8/jppres19.728_8.2.92.pdf |
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