Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression
Abstract Background Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. Results We investigated the altera...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Genetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12863-018-0660-5 |
| _version_ | 1818038450137333760 |
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| author | I-Hsuan Lin Junn-Liang Chang Kate Hua Wan-Chen Huang Ming-Ta Hsu Yi-Fan Chen |
| author_facet | I-Hsuan Lin Junn-Liang Chang Kate Hua Wan-Chen Huang Ming-Ta Hsu Yi-Fan Chen |
| author_sort | I-Hsuan Lin |
| collection | DOAJ |
| description | Abstract Background Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. Results We investigated the alteration of genome-wide transcription in mouse skeletal muscle tissue (rectus femoris muscle) during aging using a high-throughput sequencing technique. Analysis revealed significant transcriptional changes between skeletal muscles of mice at 3 (young group) and 24 (old group) months of age. Specifically, genes associated with energy metabolism, cell proliferation, muscle myosin isoforms, as well as immune functions were found to be altered. We observed several interesting gene expression changes in the elderly, many of which have not been reported before. Conclusions Those data expand our understanding of the various compensatory mechanisms that can occur with age, and further will assist in the development of methods to prevent and attenuate adverse outcomes of aging. |
| first_indexed | 2024-12-10T07:42:56Z |
| format | Article |
| id | doaj.art-f6d51848bd314e5aa677b76f7ed03681 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-12-10T07:42:56Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-f6d51848bd314e5aa677b76f7ed036812022-12-22T01:57:16ZengBMCBMC Genetics1471-21562018-08-0119111310.1186/s12863-018-0660-5Skeletal muscle in aged mice reveals extensive transformation of muscle gene expressionI-Hsuan Lin0Junn-Liang Chang1Kate Hua2Wan-Chen Huang3Ming-Ta Hsu4Yi-Fan Chen5VYM Genome Research Center, National Yang-Ming UniversityDepartment of Pathology & Laboratory Medicine, Taoyuan Armed Forces General HospitalVYM Genome Research Center, National Yang-Ming UniversityThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityInstitute of Biochemistry and Molecular Biology, National Yang-Ming UniversityThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityAbstract Background Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. Results We investigated the alteration of genome-wide transcription in mouse skeletal muscle tissue (rectus femoris muscle) during aging using a high-throughput sequencing technique. Analysis revealed significant transcriptional changes between skeletal muscles of mice at 3 (young group) and 24 (old group) months of age. Specifically, genes associated with energy metabolism, cell proliferation, muscle myosin isoforms, as well as immune functions were found to be altered. We observed several interesting gene expression changes in the elderly, many of which have not been reported before. Conclusions Those data expand our understanding of the various compensatory mechanisms that can occur with age, and further will assist in the development of methods to prevent and attenuate adverse outcomes of aging.http://link.springer.com/article/10.1186/s12863-018-0660-5AgingSkeletal muscleCardiac-related genesRNA sequencing analysisMuscle fibersDefects on differentiation |
| spellingShingle | I-Hsuan Lin Junn-Liang Chang Kate Hua Wan-Chen Huang Ming-Ta Hsu Yi-Fan Chen Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression BMC Genetics Aging Skeletal muscle Cardiac-related genes RNA sequencing analysis Muscle fibers Defects on differentiation |
| title | Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| title_full | Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| title_fullStr | Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| title_full_unstemmed | Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| title_short | Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| title_sort | skeletal muscle in aged mice reveals extensive transformation of muscle gene expression |
| topic | Aging Skeletal muscle Cardiac-related genes RNA sequencing analysis Muscle fibers Defects on differentiation |
| url | http://link.springer.com/article/10.1186/s12863-018-0660-5 |
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