The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer
Mammalian sirtuins (SIRT1–7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mech...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/5118 |
| _version_ | 1797474545565696000 |
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| author | Cosmos Ifeanyi Onyiba Christopher J. Scarlett Judith Weidenhofer |
| author_facet | Cosmos Ifeanyi Onyiba Christopher J. Scarlett Judith Weidenhofer |
| author_sort | Cosmos Ifeanyi Onyiba |
| collection | DOAJ |
| description | Mammalian sirtuins (SIRT1–7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mechanistic roles of SIRT1–7 and their downstream effects (tumor promotion or suppression) in cancers of the breast and prostate. Specifically, we highlight the involvement of sirtuins in the regulation of various proteins implicated in proliferation, apoptosis, autophagy, chemoresistance, invasion, migration, and metastasis of breast and prostate cancer. Additionally, we highlight the available information regarding SIRT1–7 regulation by miRNAs, laying much emphasis on the consequences in the progression of breast and prostate cancer. |
| first_indexed | 2024-03-09T20:31:38Z |
| format | Article |
| id | doaj.art-f6d5bab917b94c21bd04c33f29eaa2c6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:31:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f6d5bab917b94c21bd04c33f29eaa2c62023-11-23T23:22:16ZengMDPI AGCancers2072-66942022-10-011420511810.3390/cancers14205118The Mechanistic Roles of Sirtuins in Breast and Prostate CancerCosmos Ifeanyi Onyiba0Christopher J. Scarlett1Judith Weidenhofer2School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Ourimbah, NSW 2258, AustraliaSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Ourimbah, NSW 2258, AustraliaMammalian sirtuins (SIRT1–7) are involved in a myriad of cellular processes, including apoptosis, proliferation, differentiation, epithelial-mesenchymal transition, aging, DNA repair, senescence, viability, survival, and stress response. In this review, we discuss the current information on the mechanistic roles of SIRT1–7 and their downstream effects (tumor promotion or suppression) in cancers of the breast and prostate. Specifically, we highlight the involvement of sirtuins in the regulation of various proteins implicated in proliferation, apoptosis, autophagy, chemoresistance, invasion, migration, and metastasis of breast and prostate cancer. Additionally, we highlight the available information regarding SIRT1–7 regulation by miRNAs, laying much emphasis on the consequences in the progression of breast and prostate cancer.https://www.mdpi.com/2072-6694/14/20/5118sirtuinsbreastprostatecancertumormiRNA |
| spellingShingle | Cosmos Ifeanyi Onyiba Christopher J. Scarlett Judith Weidenhofer The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer Cancers sirtuins breast prostate cancer tumor miRNA |
| title | The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer |
| title_full | The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer |
| title_fullStr | The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer |
| title_full_unstemmed | The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer |
| title_short | The Mechanistic Roles of Sirtuins in Breast and Prostate Cancer |
| title_sort | mechanistic roles of sirtuins in breast and prostate cancer |
| topic | sirtuins breast prostate cancer tumor miRNA |
| url | https://www.mdpi.com/2072-6694/14/20/5118 |
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