Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium
Introduction Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been...
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Institute of Rural Health
2020-03-01
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| Series: | Annals of Agricultural and Environmental Medicine |
| Subjects: | |
| Online Access: | http://www.journalssystem.com/aaem/Selenium-prevents-lithium-accumulation-and-does-not-disturb-basic-microelement-homeostasis,105926,0,2.html |
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| author | Małgorzata Kiełczykowska Małgorzata Polz-Dacewicz Ewelina Kopciał Olga Mitrus Jacek Kurzepa Zbigniew Marzec Irena Musik |
| author_facet | Małgorzata Kiełczykowska Małgorzata Polz-Dacewicz Ewelina Kopciał Olga Mitrus Jacek Kurzepa Zbigniew Marzec Irena Musik |
| author_sort | Małgorzata Kiełczykowska |
| collection | DOAJ |
| description | Introduction
Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been continuing for some time.
Objective
The aim of the present study is to evaluate the influence of additional selenium supplementation on lithium content, as well as homeostasis of the essential microelements iron, zinc, copper and manganese in kidney and liver of rats undergoing lithium exposure.
Material and methods
The study was performed on 4 groups of male Wistar rats (6 animals each) treated with: control – saline; Li-group – Li 2 CO 3 at a dose of 2.7 mg Li/kg b.w.; Se-group – Na 2 SeO 3 at a dose of 0.5 mg Se/kg b.w.; Li+Se-group – both Li 2 CO 3 and Na 2 SeO 3 at doses of 2.7 mg Li/kg b.w. and of 0.5 mg Se/kg b.w., respectively, in the form of water solutions by stomach tube, once a day for 3 weeks. The content of the studied elements in the organ samples was determined using flame atomic absorption spectroscopy (FAAS).
Results
Lithium administered alone caused a significant increase in its content in liver and kidney. Additional supplementation with selenium reversed these effects, and did not markedly affect other studied microelements compared to control.
Conclusions
The obtained results suggest that selenium could be regarded as an adjuvant into lithium therapy. However, considering the limitations of the present study (the short duration, using only one dose and form of selenium) the continuation of the research seems to be necessary to clarify the influence of selenium supplementation on basic microelements and lithium accumulation in organs during lithium exposure. |
| first_indexed | 2024-12-11T05:24:58Z |
| format | Article |
| id | doaj.art-f6d81445ff334bb787ac5d474430a180 |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-11T05:24:58Z |
| publishDate | 2020-03-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-f6d81445ff334bb787ac5d474430a1802022-12-22T01:19:36ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632020-03-0127112913310.26444/aaem/105926105926Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithiumMałgorzata Kiełczykowska0Małgorzata Polz-Dacewicz1Ewelina Kopciał2Olga Mitrus3Jacek Kurzepa4Zbigniew Marzec5Irena Musik6Chair and Department of Medical Chemistry, Medical University, Lublin, PolandDepartment of Virology, Medical University, Lublin, PolandChair and Department of Bromatology, Medical University, Lublin, PolandChair and Department of Medical Chemistry, Medical University, Lublin, PolandChair and Department of Medical Chemistry, Medical University, Lublin, PolandChair and Department of Bromatology, Medical University, Lublin, PolandChair and Department of Medical Chemistry, Medical University, Lublin, PolandIntroduction Lithium has been used in medicine for almost seventy years. Besides beneficial effects, its therapy may cause serious side-effects, with kidney and liver being the organs most vulnerable to its harmful influence. Therefore, research on protective agents against lithium toxicity has been continuing for some time. Objective The aim of the present study is to evaluate the influence of additional selenium supplementation on lithium content, as well as homeostasis of the essential microelements iron, zinc, copper and manganese in kidney and liver of rats undergoing lithium exposure. Material and methods The study was performed on 4 groups of male Wistar rats (6 animals each) treated with: control – saline; Li-group – Li 2 CO 3 at a dose of 2.7 mg Li/kg b.w.; Se-group – Na 2 SeO 3 at a dose of 0.5 mg Se/kg b.w.; Li+Se-group – both Li 2 CO 3 and Na 2 SeO 3 at doses of 2.7 mg Li/kg b.w. and of 0.5 mg Se/kg b.w., respectively, in the form of water solutions by stomach tube, once a day for 3 weeks. The content of the studied elements in the organ samples was determined using flame atomic absorption spectroscopy (FAAS). Results Lithium administered alone caused a significant increase in its content in liver and kidney. Additional supplementation with selenium reversed these effects, and did not markedly affect other studied microelements compared to control. Conclusions The obtained results suggest that selenium could be regarded as an adjuvant into lithium therapy. However, considering the limitations of the present study (the short duration, using only one dose and form of selenium) the continuation of the research seems to be necessary to clarify the influence of selenium supplementation on basic microelements and lithium accumulation in organs during lithium exposure.http://www.journalssystem.com/aaem/Selenium-prevents-lithium-accumulation-and-does-not-disturb-basic-microelement-homeostasis,105926,0,2.htmllithiumseleniumironzinccoppermanganesemale ratsliverkidney |
| spellingShingle | Małgorzata Kiełczykowska Małgorzata Polz-Dacewicz Ewelina Kopciał Olga Mitrus Jacek Kurzepa Zbigniew Marzec Irena Musik Selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium Annals of Agricultural and Environmental Medicine lithium selenium iron zinc copper manganese male rats liver kidney |
| title | Selenium prevents lithium accumulation and does not disturb basic microelement
homeostasis in liver and kidney of rats exposed to lithium |
| title_full | Selenium prevents lithium accumulation and does not disturb basic microelement
homeostasis in liver and kidney of rats exposed to lithium |
| title_fullStr | Selenium prevents lithium accumulation and does not disturb basic microelement
homeostasis in liver and kidney of rats exposed to lithium |
| title_full_unstemmed | Selenium prevents lithium accumulation and does not disturb basic microelement
homeostasis in liver and kidney of rats exposed to lithium |
| title_short | Selenium prevents lithium accumulation and does not disturb basic microelement
homeostasis in liver and kidney of rats exposed to lithium |
| title_sort | selenium prevents lithium accumulation and does not disturb basic microelement homeostasis in liver and kidney of rats exposed to lithium |
| topic | lithium selenium iron zinc copper manganese male rats liver kidney |
| url | http://www.journalssystem.com/aaem/Selenium-prevents-lithium-accumulation-and-does-not-disturb-basic-microelement-homeostasis,105926,0,2.html |
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