Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer
BackgroundIntegration of 4D-CT ventilation function images into esophageal cancer radiation treatment planning aimed to assess dosimetric differences between different functional lung (FL) protection strategies and radiotherapy techniques.MethodsA total of 15 patients with esophageal cancer who had...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.898141/full |
| _version_ | 1798036614086131712 |
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| author | Pi-Xiao Zhou Rui-Hao Wang Hui Yu Ying Zhang Guo-Qian Zhang Shu-Xu Zhang |
| author_facet | Pi-Xiao Zhou Rui-Hao Wang Hui Yu Ying Zhang Guo-Qian Zhang Shu-Xu Zhang |
| author_sort | Pi-Xiao Zhou |
| collection | DOAJ |
| description | BackgroundIntegration of 4D-CT ventilation function images into esophageal cancer radiation treatment planning aimed to assess dosimetric differences between different functional lung (FL) protection strategies and radiotherapy techniques.MethodsA total of 15 patients with esophageal cancer who had 4D-CT scans were included. Lung ventilation function images based on Jacobian values were obtained by deformation image registration and ventilation imaging algorithm. Several different plans were designed for each patient: clinical treatment planning (non-sparing planning), the same beam distribution to FL-sparing planning, three fixed-beams FL-sparing intensity-modulated radiation therapy (IMRT) planning (5F-IMRT, 7F-IMRT, 9F-IMRT), and two FL-sparing volumetric modulated arc therapy (VMAT) planning [1F-VMAT (1-Arc), 2F-VMAT (2-Arc)]. The dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) were compared and focused on dosimetric differences in FL.ResultsThe FL-sparing planning compared with the non-sparing planning significantly decreased the FL-Dmean, V5-30 and Lungs-Dmean, V10-30 (Vx: volume of receiving ≥X Gy), although it slightly compromised PTV conformability and increased Heart-V40 (P< 0.05). The 5F-IMRT had the lowest PTV-conformability index (CI) but had a lower Lungs and Heart irradiation dose compared with those of the 7F-IMRT and 9F-IMRT (P< 0.05). The 2F-VMAT had higher PTV-homogeneity index (HI) and reduced irradiation dose to FL, Lungs, and Heart compared to those of the 1F-VMAT planning (P< 0.05). The 2F-VMAT had higher PTV conformability and homogeneity and decreased FL-Dmean, V5-20 and Lungs-Dmean, V5-10 but correspondingly increased spinal cord-Dmean compared with those of the 5F-IMRT planning (P< 0.05).ConclusionIn this study, 4D-CT ventilation function image-based FL-sparing planning for esophageal cancer can effectively reduce the dose of the FL. The 2F-VMAT planning is better than the 5F-IMRT planning in reducing the dose of FL. |
| first_indexed | 2024-04-11T21:15:21Z |
| format | Article |
| id | doaj.art-f6d99bd9fc7a454492aee8eff6874377 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T21:15:21Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f6d99bd9fc7a454492aee8eff68743772022-12-22T04:02:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.898141898141Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancerPi-Xiao ZhouRui-Hao WangHui YuYing ZhangGuo-Qian ZhangShu-Xu ZhangBackgroundIntegration of 4D-CT ventilation function images into esophageal cancer radiation treatment planning aimed to assess dosimetric differences between different functional lung (FL) protection strategies and radiotherapy techniques.MethodsA total of 15 patients with esophageal cancer who had 4D-CT scans were included. Lung ventilation function images based on Jacobian values were obtained by deformation image registration and ventilation imaging algorithm. Several different plans were designed for each patient: clinical treatment planning (non-sparing planning), the same beam distribution to FL-sparing planning, three fixed-beams FL-sparing intensity-modulated radiation therapy (IMRT) planning (5F-IMRT, 7F-IMRT, 9F-IMRT), and two FL-sparing volumetric modulated arc therapy (VMAT) planning [1F-VMAT (1-Arc), 2F-VMAT (2-Arc)]. The dosimetric parameters of the planning target volume (PTV) and organs at risk (OARs) were compared and focused on dosimetric differences in FL.ResultsThe FL-sparing planning compared with the non-sparing planning significantly decreased the FL-Dmean, V5-30 and Lungs-Dmean, V10-30 (Vx: volume of receiving ≥X Gy), although it slightly compromised PTV conformability and increased Heart-V40 (P< 0.05). The 5F-IMRT had the lowest PTV-conformability index (CI) but had a lower Lungs and Heart irradiation dose compared with those of the 7F-IMRT and 9F-IMRT (P< 0.05). The 2F-VMAT had higher PTV-homogeneity index (HI) and reduced irradiation dose to FL, Lungs, and Heart compared to those of the 1F-VMAT planning (P< 0.05). The 2F-VMAT had higher PTV conformability and homogeneity and decreased FL-Dmean, V5-20 and Lungs-Dmean, V5-10 but correspondingly increased spinal cord-Dmean compared with those of the 5F-IMRT planning (P< 0.05).ConclusionIn this study, 4D-CT ventilation function image-based FL-sparing planning for esophageal cancer can effectively reduce the dose of the FL. The 2F-VMAT planning is better than the 5F-IMRT planning in reducing the dose of FL.https://www.frontiersin.org/articles/10.3389/fonc.2022.898141/fullesophageal cancerfour-dimensional CT (4D-CT)functional lungintensity-modulated radiotherapy (IMRT)volumetric-modulated arc therapy (VMAT) |
| spellingShingle | Pi-Xiao Zhou Rui-Hao Wang Hui Yu Ying Zhang Guo-Qian Zhang Shu-Xu Zhang Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer Frontiers in Oncology esophageal cancer four-dimensional CT (4D-CT) functional lung intensity-modulated radiotherapy (IMRT) volumetric-modulated arc therapy (VMAT) |
| title | Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| title_full | Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| title_fullStr | Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| title_full_unstemmed | Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| title_short | Different functional lung-sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| title_sort | different functional lung sparing strategies and radiotherapy techniques for patients with esophageal cancer |
| topic | esophageal cancer four-dimensional CT (4D-CT) functional lung intensity-modulated radiotherapy (IMRT) volumetric-modulated arc therapy (VMAT) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.898141/full |
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